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Generating memory cytotoxic T lymphocytes through repetitive peptide boosting
Cytotoxic T lymphocytes (CTLs) play a critical role in controlling intracellular pathogens and cancer cells, and induction of memory CTLs holds promise for developing effective vaccines against critical virus infections. ...
The role of interleukin-12 for mTOR regulation of memory CTLs
A major goal of vaccines is to induce functional immune memory, and efforts to improve the efficacy of vaccines targeting memory CTLs have revealed an important immunoregulatory role of rapamycin, a specific mTOR inhibitor. ...
Lineage reprogramming of tumor-infiltrating cytotoxic T lymphocytes using protein stem cell transcription factors
Adoptive cell transfer therapy (ACT) is one of the most promising immunotherapies against cancer. However, this treatment regimen requires the expansion of a small population of effector cells, known as tumor infiltrating ...
BOVINE NEUTROPHILS RELEASE EXTRACELLULAR TRAPS UPON STIMULATION WITH OSTERTAGIA OSTERTAGI
Ostertagia ostertagi is a widespread parasite that causes significant production losses in the cattle industry. Recently discovered neutrophil extracellular traps (NETs) have been demonstrated as important effector mechanisms ...
CTL-derived exosomes enhance the activation of CTLs stimulated by low affinity peptides
Cytotoxic T cell (CTL) is the key to induce an effective immune response against infections caused by intracellular pathogens, such as virus and cancer. CTLs with low affinity can induce and maintain a substantial population ...