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Trait-based analysis of the human skin microbiome

dc.contributor.authorBewick, Sharon
dc.contributor.authorGurarie, Eliezer
dc.contributor.authorWeissman, Jake L.
dc.contributor.authorBeattie, Jess
dc.contributor.authorDavati, Cyrus
dc.contributor.authorFlint, Rachel
dc.contributor.authorThielen, Peter
dc.contributor.authorBreitwieser, Florian
dc.contributor.authorKarig, David
dc.contributor.authorFagan, William F.
dc.identifier.citationBewick, S., Gurarie, E., Weissman, J.L. et al. Trait-based analysis of the human skin microbiome. Microbiome 7, 101 (2019).en_US
dc.description.abstractThe past decade of microbiome research has concentrated on cataloging the diversity of taxa in different environments. The next decade is poised to focus on microbial traits and function. Most existing methods for doing this perform pathway analysis using reference databases. This has both benefits and drawbacks. Function can go undetected if reference databases are coarse-grained or incomplete. Likewise, detection of a pathway does not guarantee expression of the associated function. Finally, function cannot be connected to specific microbial constituents, making it difficult to ascertain the types of organisms exhibiting particular traits—something that is important for understanding microbial success in specific environments. A complementary approach to pathway analysis is to use the wealth of microbial trait information collected over years of lab-based, culture experiments.en_US
dc.publisherSpringer Natureen_US
dc.subjectSkin microbiomeen_US
dc.subjectTrait-based analysisen_US
dc.subjectEnzyme activityen_US
dc.subjectSubstrate useen_US
dc.subjectNaCl and pH rangeen_US
dc.subjectBergey’s Manual of Systematic Bacteriologyen_US
dc.titleTrait-based analysis of the human skin microbiomeen_US
dc.relation.isAvailableAtCollege of Computer, Mathematical & Physical Sciencesen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us

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