Yanagi: Fast and interpretable segment-based alternative splicing and gene expression analysis

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2019-08-13

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Gunady, M.K., Mount, S.M. & Corrada Bravo, H. Yanagi: Fast and interpretable segment-based alternative splicing and gene expression analysis. BMC Bioinformatics 20, 421 (2019).

Abstract

Ultra-fast pseudo-alignment approaches are the tool of choice in transcript-level RNA sequencing (RNA-seq) analyses. Unfortunately, these methods couple the tasks of pseudo-alignment and transcript quantification. This coupling precludes the direct usage of pseudo-alignment to other expression analyses, including alternative splicing or differential gene expression analysis, without including a non-essential transcript quantification step.

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