Localizing Chemotherapeutic Drug Release Through the Use of Polymer-Based Surgical Sealants to Treat Stage III Colorectal Cancer

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Date
2021Author
Atalla, Anthony
Coley, Morgan
Hamers, Matthew
Karodeh, Nima
McGrath, Jennifer
Minahan, Eva
Nagler, Matthew
Nassar, Yomna
Nichols, Alison
Sebastian, Ria
Tiberino, Matthew
Wendeu-Foyet, Kevin
Advisor
Kofinas, Peter
DRUM DOI
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Show full item recordAbstract
Current cancer treatments, such as systemic chemotherapy, induce several complications
that affect the entire body; localizing chemotherapy to the tumor site has the potential to
minimize harmful side effects. Solution blow spinning (SBS) offers the possibility of
incorporating chemotherapy drugs into a polymer solution through the use of a
compressed airbrush. This would allow for direct deposit of a polymer mat after
surgically removing the tumor. Sutures, in combination with polymer sealants, could be
used to prevent complications after surgery. This study focuses on stage IIIA colorectal
cancer because cancer cells have not spread distantly yet, and treatment typically
involves surgery followed by chemotherapy. Three key aims were addressed in this study
to assess polymer-drug combinations’ compatibility with SBS, observe drug release
patterns, and evaluate the effect of drug incorporation on polymer adhesion to intestinal
tissue. Our results suggested that the polymer-drug combination of
poly(L-lactide-co-ε-caprolactone) (PLCL) and capecitabine shows promise as an
adhesive surgical sealant with a drug release pattern that is complementary to a typical
resection healing timeline.
Notes
Gemstone Team TUMOR