Show simple item record

AUTOMATIC OPTIMIZATION METHODS FOR PATIENT-SPECIFIC TISSUE-ENGINEERED VASCULAR GRAFTS

dc.contributor.advisorFuge, Marken_US
dc.contributor.authorHess, Rachelen_US
dc.date.accessioned2020-10-10T05:39:41Z
dc.date.available2020-10-10T05:39:41Z
dc.date.issued2020en_US
dc.identifierhttps://doi.org/10.13016/hdd5-6ejt
dc.identifier.urihttp://hdl.handle.net/1903/26642
dc.description.abstractSurgical intervention is sometimes necessary in cases of Coarctation of the Aorta (CoA). The post-repair geometry of the aorta can result in sub-optimal hemodynamics and can have long-term health impacts. Patient-specific designs for tissue-engineered vascular grafts (TEVGs) allow greater control over post-repair geometry. This thesis proposes a method for automatically optimizing patient-specific TEVGs using computational fluid dynamics (CFD) simulations and the ANSYS Fluent adjoint solver. Our method decreases power loss in the graft by 25-60% compared to the native geometry. As patient-specific graft design can be challenging due to incomplete or uncertain flow and geometry data, this thesis also quantifies the robustness of the optimal designs with respect to CFD boundary conditions derived from imaging data. We show that using velocity conditions that deviate by more than 20% of the measured peak systolic velocity, our method produces grafts with deviations on the order of 5% in predicted power loss performance. Lastly, as one way to accelerate the optimization process, we demonstrate and compare how some established machine learning models (K Nearest Neighbors and Kernel Ridge Regression) predict reasonable starting points for an optimizer on a 2D bifurcated pipe dataset.en_US
dc.language.isoenen_US
dc.titleAUTOMATIC OPTIMIZATION METHODS FOR PATIENT-SPECIFIC TISSUE-ENGINEERED VASCULAR GRAFTSen_US
dc.typeThesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentMechanical Engineeringen_US
dc.subject.pqcontrolledMechanical engineeringen_US
dc.subject.pqcontrolledEngineeringen_US
dc.subject.pquncontrolledAdjoint optimizationen_US
dc.subject.pquncontrolledCoarctation of the aortaen_US
dc.subject.pquncontrolledComputational fluid dynamicsen_US
dc.subject.pquncontrolledOptimizationen_US
dc.subject.pquncontrolledTissue-engineered vascular graftsen_US
dc.subject.pquncontrolledTopology optimizationen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record