African-Americans (AAs) have higher rates of cardiovascular disease (CVD), including hypertension and stroke, as compared to their Caucasian-American (CA) counterparts. High resting concentrations of systemic inflammatory biomarkers contribute to vascular dysfunction and are predictive of future cardiovascular events; differential resting levels of inflammatory markers between groups may reveal increased potential for CVD in at-risk groups. Additionally, impaired endothelial function and increased arterial stiffness, subclinical measures of CVD progression, have been reported in AA groups. The purpose of this study was to examine race differences between young, healthy AA and CA adults after a systemic inflammatory stimulus and subsequent endothelial responses to inflammation. Endothelial function, arterial stiffness, and hemodynamic variables were measured. The results suggest there were no race differences in vascular function or hemodynamic responses following an acute inflammatory stimulus.