With the growing acceptance and better understanding of the importance of uncertainties in seismic design, traditional design approaches with deterministic analysis are being replaced with more reliable approaches within a risk-based context. Recently, resilience has been increasingly studied as a comprehensive metric to assess the ability of a system to withstand and recover from disturbances with large uncertainties. For civil infrastructure systems susceptible to natural hazards, especially earthquakes as considered herein, seismic resilience could provide a measurement integrating both earthquake and post-earthquake performance. For structural engineers, improving infrastructure disaster resilience starts with the design of more resilient structures. This requires a quantitative approach to explicitly guild the design towards better resilience.

However, when attempting to quantify the seismic resilience of a structure, large uncertainties lead to large computational costs associated with risk-based approaches. Additionally, the accuracy of numerical simulations under wide range of design scenarios is unknown. To address these challenges, this dissertation investigates the role of seismic resilience in structural design. This dissertation starts with a novel seismic protective device to improve structural resilience and follows with the development of a quantitative and efficient design, evaluation, and optimization framework for seismic resilience. This framework proposes metamodeling through deep neural networks for improved efficiency and cyber-physical systems for improved accuracy. Feedforward neural networks are adopted for fragility metamodeling, while online learning long-short term memory neural networks are developed for structural component metamodeling. Real-time hybrid simulation is used for the construction of cyber-physical systems. The proposed framework is demonstrated to have both improved accuracy and significantly reduced computational/experimental cost when compared to existing approaches. The applicability of the framework is illustrated through the optimization of structural systems for improved seismic resilience.