Spatial and temporal variation of snow in High Mountain Asia is very critical as it determines contribution of snowmelt to the freshwater supply of over 136 million people. Support vector machine (SVM) prediction of passive microwave brightness temperature spectral difference (ΔTb) as a function of NASA Land Information System (LIS) modeled geophysical states is investigated through a sensitivity analysis. AMSRE ΔTb measurements over snow-covered areas in the Indus basin are used for training the SVMs. Sensitivity analysis results conform with the known first-order physics. LIS input states that are directly linked to physical temperature demonstrate relatively higher sensitivity. Accuracy of LIS modeled states is further assessed through a comparative analysis between LIS derived and Advanced Scatterometer based Freeze/Melt/Thaw categorical datasets. Highest agreement of 22%, between the two datasets, is observed for freeze state. Analyses results provide insight into LIS’s land surface modeling ability over the Indus Basin.