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    Latent and Abnormal Functional Connectivity Circuits in Autism Spectrum Disorder

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    Date
    2017-03-21
    Author
    Chen, Shuo
    Xing, Yishi
    Kang, Jian
    Citation
    Chen S, Xing Y and Kang J (2017) Latent and Abnormal Functional Connectivity Circuits in Autism Spectrum Disorder. Front. Neurosci. 11:125. doi: 10.3389/fnins.2017.00125
    DRUM DOI
    https://doi.org/10.13016/M2CR5NC67
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    Abstract
    Autism spectrum disorder (ASD) is associated with disrupted brain networks. Neuroimaging techniques provide noninvasive methods of investigating abnormal connectivity patterns in ASD. In the present study, we compare functional connectivity networks in people with ASD with those in typical controls, using neuroimaging data from the Autism Brain Imaging Data Exchange (ABIDE) project. Specifically, we focus on the characteristics of intrinsic functional connectivity based on data collected by resting-state functional magnetic resonance imaging (rs-fMRI). Our aim was to identify disrupted brain connectivity patterns across all networks, instead of in individual edges, by using advanced statistical methods. Unlike many brain connectome studies, in which networks are prespecified before the edge connectivity in each network is compared between clinical groups, we detected the latent differentially expressed networks automatically. Our network-level analysis identified abnormal connectome networks that (i) included a high proportion of edges that were differentially expressed between people with ASD and typical controls; and (ii) showed highly-organized graph topology. These findings provide new insight into the study of the underlying neuropsychiatric mechanism of ASD.
    Notes
    Partial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund.
    URI
    http://hdl.handle.net/1903/19695
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