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Fabrication of Poly (D,L-Lactic-Co-Glycolic Acid) Microparticles for Improved Human Papillomavirus Vaccine Delivery

dc.contributor.advisorFisher, John P.
dc.contributor.authorBrown, Rachel
dc.contributor.authorCesewski, Ellen
dc.contributor.authorFix, Jonathan
dc.contributor.authorFreudenberger, Devon
dc.contributor.authorHiggins, Kara
dc.contributor.authorMcMahon, Eileen
dc.contributor.authorNiba, Vanessa
dc.contributor.authorPark, Hoon
dc.contributor.authorPerdomo, Gabriela
dc.contributor.authorSeo, Anna
dc.contributor.authorSrivastava, Avantika
dc.contributor.authorTsui, Christina
dc.contributor.authorWhiteman, Aaron
dc.contributor.authorZubajlo, Rebecca
dc.description.abstractHuman papillomavirus (HPV) is the leading cause of cervical cancer and the most prevalent sexually transmitted disease worldwide. HPV vaccines require a multi-dose regimen to provide immunity, contributing to low patient compliance. We addressed this problem by formulating biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) microparticles and assessing their viability for use in controlled-release vaccines. We hypothesized that we could alter fabrication parameters to produce 1-10 μm microparticles in order to encapsulate ovalbumin (OVA) and HPV virus-like particles (VLPs). Microparticles were fabricated using a double emulsion method and used to elicit an immune response in JAWSII cells. Our results contribute to knowledge of vaccine delivery mechanisms and controlled-release technology, and could contribute to the creation of a viable controlled-release HPV vaccine.en_US
dc.subjectHuman papillomavirus (HPV)en_US
dc.subjectcontrolled-release vaccinesen_US
dc.subjectGemstone Team EPIDEMICSen_US
dc.titleFabrication of Poly (D,L-Lactic-Co-Glycolic Acid) Microparticles for Improved Human Papillomavirus Vaccine Deliveryen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)

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