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    Fabrication of Poly (D,L-Lactic-Co-Glycolic Acid) Microparticles for Improved Human Papillomavirus Vaccine Delivery

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    No. of downloads: 579

    Date
    2015
    Author
    Brown, Rachel
    Cesewski, Ellen
    Fix, Jonathan
    Freudenberger, Devon
    Higgins, Kara
    McMahon, Eileen
    Niba, Vanessa
    Park, Hoon
    Perdomo, Gabriela
    Seo, Anna
    Srivastava, Avantika
    Tsui, Christina
    Whiteman, Aaron
    Zubajlo, Rebecca
    Advisor
    Fisher, John P.
    DRUM DOI
    https://doi.org/10.13016/M2F92J
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    Abstract
    Human papillomavirus (HPV) is the leading cause of cervical cancer and the most prevalent sexually transmitted disease worldwide. HPV vaccines require a multi-dose regimen to provide immunity, contributing to low patient compliance. We addressed this problem by formulating biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) microparticles and assessing their viability for use in controlled-release vaccines. We hypothesized that we could alter fabrication parameters to produce 1-10 μm microparticles in order to encapsulate ovalbumin (OVA) and HPV virus-like particles (VLPs). Microparticles were fabricated using a double emulsion method and used to elicit an immune response in JAWSII cells. Our results contribute to knowledge of vaccine delivery mechanisms and controlled-release technology, and could contribute to the creation of a viable controlled-release HPV vaccine.
    URI
    http://hdl.handle.net/1903/16766
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    DRUM is brought to you by the University of Maryland Libraries
    University of Maryland, College Park, MD 20742-7011 (301)314-1328.
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