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Exopolysaccharide Analysis and EPS Depolymerases as Possible Biofilm Control Strategies

dc.contributor.advisorNelson, Danielen_US
dc.contributor.authorBales, Patricken_US
dc.date.accessioned2014-10-11T05:44:55Z
dc.date.available2014-10-11T05:44:55Z
dc.date.issued2014en_US
dc.identifierhttps://doi.org/10.13016/M2FG6S
dc.identifier.urihttp://hdl.handle.net/1903/15745
dc.description.abstractBacteria form biofilms by adhering to surfaces and secreting high molecular weight macromolecules. When in the biofilm mode of growth, bacteria possess increased resistance to the action of antimicrobials and the immune system. By gaining an increased understanding of the structure of the biofilm extrapolymeric substance (EPS) and investigating ways to break up the EPS matrix, more effective treatment of biofilm-related infections can be achieved. In this thesis, the isolation and characterization of the polysaccharide portion of the EPS of several bacterial species is reported. The identification of 14 possible biofilm-degrading enzymes is described. One of these enzymes, HexNW, is shown to be highly thermostable and effective as a biofilm treatment.en_US
dc.language.isoenen_US
dc.titleExopolysaccharide Analysis and EPS Depolymerases as Possible Biofilm Control Strategiesen_US
dc.typeThesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentMolecular and Cell Biologyen_US
dc.subject.pqcontrolledMicrobiologyen_US
dc.subject.pqcontrolledBiochemistryen_US
dc.subject.pqcontrolledMolecular biologyen_US
dc.subject.pquncontrolledBiofilmsen_US
dc.subject.pquncontrolledDepolymeraseen_US
dc.subject.pquncontrolledDispersinen_US
dc.subject.pquncontrolledThermostableen_US


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