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The Impact of Prenatal Nicotine Exposure on Impulsivity and Neural Firing in the Medial Prefrontal Cortex

dc.contributor.advisorRoesch, Matthew R.
dc.contributor.authorBarnett, Brian
dc.contributor.authorCohen, Valerie
dc.contributor.authorHearn, Taylor
dc.contributor.authorJones, Emily
dc.contributor.authorKariyil, Reshma
dc.contributor.authorKunin, Alice
dc.contributor.authorKwak, Sen
dc.contributor.authorLee, Jessica
dc.contributor.authorLubinski, Brooke
dc.contributor.authorRao, Gautam
dc.contributor.authorZhan, Ashley
dc.date.accessioned2014-07-16T13:41:18Z
dc.date.available2014-07-16T13:41:18Z
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/1903/15539
dc.description.abstractPrenatal nicotine exposure (PNE) is linked to a large number of psychiatric disorders, including attention deficit hyperactivity disorder (ADHD). Current literature suggests that core deficits observed in ADHD reflect abnormal inhibitory control governed by the prefrontal cortex (PFC) of the brain. The PFC is structurally altered by PNE, but it is still unclear how neural firing is affected during tasks that test behavioral inhibition, such as the stop-signal task, or if neural correlates related to inhibitory control are affected after PNE in awake behaving animals. To address these questions, we recorded from single medial PFC (mPFC) neurons in control rats and PNE rats as they performed our stopsignal task. We found that PNE rats were faster for all trial types and were less likely to inhibit the behavioral response on STOP trials. Neurons in mPFC fired more strongly on STOP trials and were correlated with accuracy and reaction time. Although the number of neurons exhibiting significant modulation during task performance did not differ between groups, overall activity in PNE was reduced. We conclude that PNE makes rats impulsive and reduces firing in mPFC neurons that carry signals related to response inhibition.en_US
dc.language.isoen_USen_US
dc.subjectPrefrontal cortexen_US
dc.subjectNicotineen_US
dc.subjectNeuronsen_US
dc.subjectGemstone Team RITALINen_US
dc.titleThe Impact of Prenatal Nicotine Exposure on Impulsivity and Neural Firing in the Medial Prefrontal Cortexen_US
dc.typeThesisen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)


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