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    The Application of an Exogenous Linear and Radial Electrical Field to an In Vitro Chronic Diabetic Ulcer Model for Evaluation as a Potential Treatment

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    ELECTRODE_Final_Thesis.docx (20.67Mb)
    No. of downloads: 376

    Date
    2014
    Author
    Ahmed, Sagah
    Anzures, Natalie
    Bosley, Zachary
    Bui, Brendan
    Feizi, Ariana
    Jawahery, Sudi
    Koenig, Courtney
    Lakomy, Katherine
    Lin, Megan
    Natarajan, Poorna
    Nathan, Eisha
    Sayed, Hiba
    Solano, Eduardo
    Advisor
    Fisher, John
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    Abstract
    Chronic diabetic ulcers affect approximately 15% of patients with diabetes worldwide. Currently, applied electric fields are being investigated as a reliable and cost-effective treatment. This in vitro study aimed to determine the effects of a constant and spatially variable electric field on three factors: endothelial cell migration, proliferation, and angiogenic gene expression. Results for a constant electric field of 0.01 V demonstrated that migration at short time points increased 20-fold and proliferation at long time points increased by a factor of 1.40. Results for a spatially variable electric field did not increase directional migration, but increased proliferation by a factor of 1.39 and by a factor of 1.55 after application of 1.00 V and 0.01 V, respectively. Both constant and spatially variable applied fields increased angiogenic gene expression. Future research that explores a narrower range of intensity levels may more clearly identify the optimal design specifications of a spatially variable electric field.
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    http://hdl.handle.net/1903/15531
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