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    Drug Delivery through the Blood-Brain Barrier through Use of Vascular Cell Adhesion Molecule 1- Targeted Nanoparticles

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    No. of downloads: 366

    Date
    2013
    Author
    Adnan, Sakib
    Borsellino, Regina
    He, Alice
    Mukherjee, Somdutta
    Peng, Victor
    Potti, Karthya
    Shih, Kelly
    Vaitkus, Janina
    Wang, Victor
    Woo, Rani
    Zhang, Robert
    Advisor
    Aranda-Espinoza, Jose Helim
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    Abstract
    The blood brain barrier (BBB) is a semi-permeable membrane separating the brain from the bloodstream, preventing many drugs that treat neurological diseases, such as Alzheimer’s and Parkinson’s, from reaching the brain. Our project aimed to create a novel drug delivery system targeting the brain during neural inflammation. We developed a cationic solid lipid nanoparticle (CSLN) complex composed of cationic nanoparticles, biotin, streptavidin, and anti-vascular cell adhesion molecule-1 (anti- VCAM-1) antibodies. The anti-VCAM-1 antibody is used to target VCAM-1, a cell adhesion protein found on the BBB endothelium. VCAM-1 expression is elevated in the presence of inflammatory molecules, such as tumor necrosis factor-alpha (TNF- α). Through the use of a simple BBB model, results showed that our novel drug delivery system experienced some level of success in targeting the brain inflammation due to increasing TNF-α concentrations. This is promising for drug delivery research and provides support for VCAM-1 targeting using more robust and complex BBB models.
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    http://hdl.handle.net/1903/13876
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    DRUM is brought to you by the University of Maryland Libraries
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