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Mechanistic investigations of stoichiometric and catalytic Pt-mediated oxidative functionalization at a proximal boron center
(2013)
The focus of the work detailed in this dissertation is the investigation of mechanism and catalytic applications of Pt complexes supported by novel anionic di(2-pyridyl)borate ligands.
It was found that oxidation of ...
Trapping Labile Adducts Formed Between an ortho-Quinone Methide and DNA
(2012)
Exogenously generated electrophiles are capable of alkylating DNA. If not repaired, the resulting DNA adducts can lead to mutations and either cancer or cell death. Electrophilic ortho-quinone methides (o-QM) are reactive ...
DESIGN AND SYNTHESIS OF AN ELECTRON RICH QUINONE METHIDE PRECURSOR FOR SEQUENCE -DIRECTED ALKYLATION OF DNA
(2012)
Quinone methides (QM) can be delivered to alklyate specific sites with a single strand DNA through target promoted alkylation. Previous experimental results indicated that alkylation by DNA-QM self-adduct was too slow for ...
Templated Synthesis of Glycoluril Oligomers and Monofunctionalized Cucurbit[6]uril Derivatives
(2011)
The molecular recognition properties exhibited by molecular containers have inspired supramolecular chemists to generate diverse and specialized macrocycles. The family of hosts known as cucurbiturils (CB[n]) have become ...
Silencing bacteria with small molecules
(2014)
Quorum sensing (QS) is a phenomenon in bacteria where the accumulation of extracellular signaling molecules (autoinducers, AIs), which enable bacterial cells to sense neighboring cells (population density), reaches certain ...
Tailoring Guanosine Hydrogels for Various Applications
(2018)
Supramolecular hydrogels are of current interest for their ease of use, potential biocompatibility, and reactivity to stimuli. These gel materials have found use in a number of fields ranging from drug delivery and tissue ...
Applications of Photoinduced Electron Transfer Chemistry: Photoremovable Protecting Groups and Carbon Dioxide Conversion
(2016)
Traditional organic chemistry has long been dominated by ground state thermal reactions. The alternative to this is excited state chemistry, which uses light to drive chemical transformations. There is considerable interest ...
Functionalized Acyclic Cucurbit[n]uril Molecular Containers as Reversal Agents for Drugs
(2017)
The study of molecular containers has a prominent place in the scientific literature with many applications, including drug reversal. The clinical use of the cyclodextrin based reversal agent BridionTM has greatly improved ...
Bringing New Chemistry to Guanosine Hydrogels
(2020)
Molecular self-assembly is a powerful method to construct functional materials such as supramolecular hydrogels. Hydrogels contain mostly water but show solid-like rheology. Nucleosides and nucleotides contain rich recognition ...
Mechanistic Studies of Photochemical Reactions: Photoacid Generators, Photoreleaseable Protecting Groups, and Diarylnitrenium Ions
(2021)
The use of light to drive chemical reactions is becoming increasingly popular due to the enhanced spatial and temporal control provided. Because of this, it is important to understand how these photochemical transformations ...