Search
Now showing items 1-10 of 33
Branching activity switches actin network between connected and fragmented states in a myosin-dependent manner
(2021)
Actin networks rely on nucleation mechanisms to generate new filaments because de-novo nucleation is kinetically disfavored. Branching nucleation of actin filaments by Arp2/3, in particular, is critical for actin ...
MECHANISTIC STUDY AND THE DESIGN OF IRON-CATALYZED MULTI-COMPONENT CROSS-COUPLING REACTION
(2021)
Cross-coupling reactions (CCRs) are one of the most versatile methods for the formation of C-C bonds. Traditionally, palladium and nickel are broadly used as the catalyst in this type of transformation. However, due to the ...
CHARACTERIZATION OF THE STRUCTURE AND BINDING OF BRANCHED K6/K48-LINKED AND BRANCHED K6/63-LINKED POLYUBIQUITIN CHAINS
(2021)
Ubiquitin (Ub) is an important post-translational protein modifier in eukaryotes. Post-translational modification with Ub is an essential process for eukaryotic cellular signaling including protein degradation, DNA repair, ...
RAPID HEATING AND CHEMICAL SPECIATION CHARACTERIZATION FOR COMBUSTION PERFORMANCE ANALYSIS OF METALLIZED, NANOSCALE THERMITES AND PVDF BOUND SOLID PROPELLANT COMPOSITIONS
(2021)
Energetic materials research focuses on performance analysis of cost-effective solid materials which safely, precisely, and efficiently transitions stored chemical potential energy to kinetic energy at a rate throttled ...
Molecular Simulation and Spectroscopy of a Strong Multipolar Fluid
(2021)
Acetonitrile (CH3CN) is a small, aprotic molecule. The apparent simplicity of this species belies great complexity in its organization and dynamics in the liquid state. Additionally, at silica surfaces, liquid acetonitrile ...
EMERGENT NETWORK ORGANIZATION IN LINEAR AND DENDRITIC ACTIN NETWORKS REVEALED BY MECHANOCHEMICAL SIMULATIONS
(2021)
Cells employ networks of filamentous biopolymers to achieve shape changes and exert migratory forces. As the networks offer structural integrity to a cell, they are referred to as the cytoskeleton. Actin is an essential ...
INVESTIGATION OF ORDERED POROUS MATERIALS FOR LITHIUM AND MAGNESIUM IONS ELECTROCHEMICAL ENERGY STORAGE
(2021)
As portable electronics and electric vehicles become a more integral part of everyday life, rechargeable electrical energy storage devices (batteries) capable of providing greater energy and power densities will soon be ...
SYNTHESIS OF PNAG ANALOGS TO PROFILE BIOFILM GLYCOSIDASES
(2021)
Bacteria biofilms consisting of surface-attached bacterial communities embedded in an extracellular matrix serve as a defense mechanism for many medically important bacterial species. Exopolysaccharides of partially ...
DISCOVERY OF A POTENT AND SELECTIVE RIOK1 INHIBITOR ACTIVE IN CRC CELL LINES USING STRUCTURE-BASED DRUG DESIGN
(2021)
Colorectal cancer (CRC) is the second leading cause of cancer-related death in the United State. CRC has aggressive malignancy characterized by poor prognosis and its metastasis and recurrence is the cancer stem cell driven. ...
EPIGENETICS TUNE CHROMATIN MECHANICS, A COMPUTATIONAL APPROACH
(2021)
The base unit of DNA packaging in eukaryotes, the nucleosome, is adaptively modified for epigenetic control. Given the vast chemical space of chromatin and complexity of signaling and expression, much of our knowledge about ...