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Mechanistic investigations of stoichiometric and catalytic Pt-mediated oxidative functionalization at a proximal boron center
(2013)
The focus of the work detailed in this dissertation is the investigation of mechanism and catalytic applications of Pt complexes supported by novel anionic di(2-pyridyl)borate ligands.
It was found that oxidation of ...
Trapping Labile Adducts Formed Between an ortho-Quinone Methide and DNA
(2012)
Exogenously generated electrophiles are capable of alkylating DNA. If not repaired, the resulting DNA adducts can lead to mutations and either cancer or cell death. Electrophilic ortho-quinone methides (o-QM) are reactive ...
DIRHODIUM CAPROLACTAMATE CATALYZED OXIDATIONS BY TERT-BUTYL HYDROPEROXIDE. FROM MECHANISMS TO NEW METHODOLOGIES
(2012)
Dirhodium caprolactamate, Rh<sub>2</sub>(cap)<sub>4</sub>, is a very efficient catalyst for the generation of the <italic>tert</italic>-butylperoxy radical from <italic>tert</italic>-butyl hydroperoxide, and the ...
DESIGN AND SYNTHESIS OF AN ELECTRON RICH QUINONE METHIDE PRECURSOR FOR SEQUENCE -DIRECTED ALKYLATION OF DNA
(2012)
Quinone methides (QM) can be delivered to alklyate specific sites with a single strand DNA through target promoted alkylation. Previous experimental results indicated that alkylation by DNA-QM self-adduct was too slow for ...
Characterization and Investigation of Benzylic Carbenium Ion and Carbanion Ion-Diradical Intermediates With 3,5-Disubstituted (pi)-Donors/Acceptors
(2012)
High-spin magnetic materials have been based on monomeric units that contain metals. Far less research has been done to develop and characterize alternative high-spin building blocks consisting of mostly organic subunits. ...
Total Synthesis of an Oxidation Product of gamma-Carotene - a ProVitamin A Food Carotenoid
(2011)
Human serum carotenoids and their metabolites are known to function as antioxidants and inflammation mediators. In 1992, two oxidative metabolites of lycopene were isolated from human serum and tomato-based food products. ...
Templated Synthesis of Glycoluril Oligomers and Monofunctionalized Cucurbit[6]uril Derivatives
(2011)
The molecular recognition properties exhibited by molecular containers have inspired supramolecular chemists to generate diverse and specialized macrocycles. The family of hosts known as cucurbiturils (CB[n]) have become ...
Bioorganic Chemistry of Prodigiosenes: Anion Transport, Basicity, Conformation and G-Quadruplex DNA Binding
(2015)
Naturally occurring prodigiosenes are produced by microorganisms such as Streptomyces and Serratia marcescens. Prodigiosenes are fascinating for their wide range of biological activities in the form of anti-cancer, ...
Building Block Synthesis and Recognition Properties of Cucurbit[n]uril (n = 7, 8) Derivatives
(2015)
Molecular containers have been a topic of interest for chemists since the discovery of crown ethers and their molecular recognition properties in the late 1960’s. Since then, the field of molecular containers has expanded ...
ADVANCES IN SILOXANE-BASED COUPLING TECHNOLOGIES: APPROACHES TOWARD PANCRATISTATIN AND STREPTONIGRIN
(2014)
The ability to form carbon-carbon bonds, arguably the most important transformation in synthetic chemistry, has been critically facilitated via the implementation of transition metal catalysts with main group element-associated ...