Search
Now showing items 1-10 of 22
PRINCIPLES OF COMPLEX POLYUBIQUITIN SIGNALING, THE STRUCTURAL BASIS FOR UBIQUITIN-UBISTATIN INTERACTIONS, AND NOVEL ASSAYS FOR THE CHARACTERIZATION OF DEUBIQUITINASES
(2013)
Ubiquitination is the most versatile and is certainly one of the most difficult post-translation modifications to understand in eukaryotic life. In the process of ubiquitination the C-terminus of ubiquitin (Ub), a small ...
THE DYNAMICS OF DIUBIQUITIN REVEALED BY NMR: WHAT IS THE DRIVING FORCE BETWEEN THE OPEN AND CLOSED STATES?
(2012)
The K48-linked polyubiquitin chains are important signals for proteasomal degradation and other biological processes. Their recognition of ubiquitin binding partners such as the UBA2 (ubiquitin associated domain 2) domain ...
CHARACTERIZATION OF BRANCHED HISTIDINE-LYSINE POLYPEPTIDES USED FOR NUCLEIC ACID DELIVERY AND THEIR COMPLEXES WITH DNA AND SMALL INTERFERING RNA.
(2013)
DNA and siRNA must be packaged for protection prior to transfection in vivo when they are administered to humans or other animals. Dr. A. J. Mixson's laboratory at the University of Maryland, Baltimore Medical School has ...
SINGLE MOLECULE FRET OF LACI-DNA-IPTG LOOP CONFORMATIONS
(2012)
This work focuses on the <italic>Escherichia coli</italic> lactose repressor protein (LacI) which represses expression of the lac operon. In order to repress transcription, the tetrameric LacI protein binds a primary ...
PRINCIPLES OF INFORMATION PROCESSING IN NEURONAL AVALANCHES
(2011)
How the brain processes information is poorly understood. It has been suggested that the imbalance of excitation and inhibition (E/I) can significantly affect information processing in the brain. Neuronal avalanches, a ...
Using Energy Landscape Theory to Uncover the Organization of Conformational Space of Proteins in Their Native States.
(2011)
The functional motions of proteins navigate on rugged energy landscapes. Hence, mapping of these multidimensional landscapes into lower dimensional manifolds is imperative for gaining deeper insights into the functional ...
USING SINGLE MOLECULE TECHNIQUES TO DETERMINE THE MECHANISM OF DNA TOPOLOGY SIMPLIFICATION BY TYPE IIA TOPOISOMERASES
(2011)
Type IIA topoisomerases are essential, universally conserved proteins that modify DNA topology by passing one segment of duplex DNA (the transfer, or T-segment) through a transient double strand break in a second segment ...
Differentiating a Landscape of Lac Repressor Mediated DNA Loops Using FRET
(2011)
The variety of DNA loops formed by a protein such as Lac Repressor (LacI), predicted to populate multiple loop topologies and geometries, increases the uncertainty of models that have not been experimentally verified. We ...
Conformational Sampling and Calculation of Molecular Free Energy Using Superposition Approximations
(2011)
The superposition approximations (SAs), first proposed in the distribution function theories of liquids, are a family of approximations to a multivariate probability distribution function (pdf) in terms of its lower order ...
BIOPHYSICAL STUDIES OF THE MECHANISM OF CERAMIDE CHANNEL DESTABLIZATION BY BCL-XL IN APOPTOSIS AND THE USE OF RECTIFICATION TO PROBE THE STRUCTURE AND DYNAMICS OF A NOVEL ESCHERICHIA COLI CHANNEL
(2015)
Ceramide forms a novel type of channel in the mitochondrial outer membrane and these channels are involved the release of intermembrane space proteins from mitochondria, a decision-making step in the apoptotic process. An ...