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Branching activity switches actin network between connected and fragmented states in a myosin-dependent manner
Actin networks rely on nucleation mechanisms to generate new filaments because de-novo nucleation is kinetically disfavored. Branching nucleation of actin filaments by Arp2/3, in particular, is critical for actin ...
EMERGENT NETWORK ORGANIZATION IN LINEAR AND DENDRITIC ACTIN NETWORKS REVEALED BY MECHANOCHEMICAL SIMULATIONS
Cells employ networks of filamentous biopolymers to achieve shape changes and exert migratory forces. As the networks offer structural integrity to a cell, they are referred to as the cytoskeleton. Actin is an essential ...