Now showing items 31-40 of 553
PRINCIPLES OF COMPLEX POLYUBIQUITIN SIGNALING, THE STRUCTURAL BASIS FOR UBIQUITIN-UBISTATIN INTERACTIONS, AND NOVEL ASSAYS FOR THE CHARACTERIZATION OF DEUBIQUITINASES
Ubiquitination is the most versatile and is certainly one of the most difficult post-translation modifications to understand in eukaryotic life. In the process of ubiquitination the C-terminus of ubiquitin (Ub), a small ...
CHEMICAL FUNCTIONALIZATION OF CARBON NANOTUBES FOR CONTROLLED OPTICAL, ELECTRICAL AND DISPERSION PROPERTIES
A carbon nanotube is a graphitic sheet, rolled into a one-dimensional, hollow tube. This structure provides certain individual nanotubes with high conductivity and near-infrared optical activity. These properties are not ...
Synthesis and Application of Double Cavity Cucurbit[n]urils
Molecular containers are a unique set of compounds that are able to recognize and associate with other molecules. It is these molecular recognition properties that has resulted in a large number of research groups studying ...
COMPUTER SIMULATIONS OF PROTEIN FOLDING
Understanding how proteins fold and interact with each other is key to understanding virtually all biological processes. Recent advances in computer power and modeling techniques make it possible to study proteins and other ...
Book of Abstracts: 8th International Symposium on Macrocyclic and Supramolecular Chemistry
This pdf file is the finalized version of the book of abstracts for the 8th International Symposium on Macrocyclic Chemistry held in Arlington, Virginia, USA from July 7-11, 2013
THE DYNAMICS OF DIUBIQUITIN REVEALED BY NMR: WHAT IS THE DRIVING FORCE BETWEEN THE OPEN AND CLOSED STATES?
The K48-linked polyubiquitin chains are important signals for proteasomal degradation and other biological processes. Their recognition of ubiquitin binding partners such as the UBA2 (ubiquitin associated domain 2) domain ...
Trapping Labile Adducts Formed Between an ortho-Quinone Methide and DNA
Exogenously generated electrophiles are capable of alkylating DNA. If not repaired, the resulting DNA adducts can lead to mutations and either cancer or cell death. Electrophilic ortho-quinone methides (o-QM) are reactive ...
Alterations in the Primary Structures of Ribosomal Proteins in Acquired Drug Resistance
Acquired drug resistance is a multifactorial process that is one of the major causes for cancer treatment failure. The anticancer drug, mitoxantrone, was recently determined to inhibit ribosome biogenesis. Changes in ...
MESOPOROUS SILICA NANOPARTICLES AS DRUG DELIVERY SYSTEMS AND DIAGNOSTIC TOOLS
Micro- and nano-scale silica materials have recently gained attention due to their potential as biosensors, site-specific drug delivery systems and diagnostic tools. Accordingly, examples of the preparation and use of ...
The conformational landscape of RNA translational regulators and their potential as drug discovery targets
RNA is an underutilized target for drug discovery. Once thought to be a passive carrier of genetic information, RNA is now known to play a critical role in essentially all aspects of biology including signaling, gene ...