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Fundamentals of Excess Electron Transport in Biologically Relevant Systems
(2008-01-25)
Thymine dimers are premutagenic lesions that form via ultraviolet irradiation of DNA. While the distribution of thymine dimers is non-random, it is also not yet predictable. Thymine dimer accumulation is likely to be ...
PALLADIUM-CATALYZED ALLYLIC-ARYLATION: MECHANISTIC STUDIES AND APPLICATION TO THE TOTAL SYNTHESIS OF (+/-)-7-DEOXYPANCRATISTATIN DERIVATIVES
(2009)
Palladium-catalyzed carbon-carbon bond formation is one of the most widely used reactions for the synthesis of biologically active substances. The DeShong group has demonstrated that hypervalent silicates can be employed ...
Insight into the Structure and Mechanism of Iodotyrosine Deiodinase, the First Mammalian Member of the NADH Oxidase / Flavin Reductase Superfamily
(2006-07-18)
Iodotyrosine deiodinase (IYD) has remained poorly characterized for nearly 50 years in spite of its function as an iodine salvage pathway and its role in regulation of mammalian basal metabolism. IYD catalyzes the reductive ...
Total Synthesis of (3R,3'R,6'R)-Lutein, (3R,3'R)-Zeaxanthin and Their Stereoisomers
(2008)
(3R,3'R,6'R)-Lutein (1) and (3R,3'R)-zeaxanthin (5) are dietary carotenoids that are found in most fruits and vegetables. Numerous studies have shown that 1 and 5 play an important role in the prevention of age-related ...
Hypercoordinate Silicon Compounds In Organic Synthesis: Improved Methods For The Synthesis Of Aryl(Trialkoxy)Silane Derivatives; And Trimethylsilyl Cyanide As A Cyanide Source For Nucleophilic Substitution
(2004-04-26)
Palladium-catalyzed cross-coupling reactions are versatile methods for the synthesis of carbon-carbon bonds. The Stille and Suzuki cross-coupling protocols have achieved prominence in the synthesis of pharmaceuticals and ...
REVERSIBLE QUINONE METHIDE ALKYLATION OF DNA
(2009)
Alkylation of DNA has been found to cause cancer and also to serve as its treatment. Quinone methides (QMs) are highly electrophilic molecules implicated in numerous metabolism processes. Studies of QM's reversible ...
Visible Light Photorelease of Carboxylate Anions by Mediated Photoinduced Electron Transfer to Pyridinium-based Protecting Groups
(2009)
The use of sensitized photoinduced electron transfer (PET) to trigger release of redox-active photoremovable protecting groups (PRPGs) allows a broad range of chromophores to be selected that absorb in difference wavelength ...
Synthetic Approaches to the Anticancer Agent Streptonigrin
(2005-09-23)
Pd-catalyzed coupling reactions have a central place in synthetic chemistry. In particular, studies from the DeShong laboratory have demonstrated that aryltrialkoxysilanes, in the presence of Pd(0) and fluoride, are capable ...
The Redox Chemistry of Dirhodium Carboxamidates: From Fundamental Structures to Catalytic Functions.
(2008-03-24)
Redox chemistry is the study of molecular structure and function associated with changes in oxidation state. In this manuscript, the structures and functions of dinuclear rhodium complexes in various oxidation states are ...
Synthesis of Highly Functionalized Diazoacetoacetates and Their Synthetic Applications
(2006-11-20)
ABSTRACT
Title of dissertation: SYNTHESIS OF HIGHLY FUNCTIONALIZED
DIAZOACETOACETATES AND THEIR SYNTHETIC APPLICATIONS
Kousik Kundu, Doctor of Philosophy, 2006
Dissertation directed by: Professor Michael ...