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Now showing items 21-30 of 98
STRUCTURAL STUDY OF THE EARLY SECRETORY PROTEIN B AND ATYPICAL RIO2 KINASE
(2015)
Mycobacterium tuberculosis, Mtb, is a successful pathogen that secretes variety of proteins to manipulate the host defense mechanisms and create a proper environment for its survival. The progression of the disease depends ...
PROTEOMIC CHARACTERIZATION OF EXOSOMES SHED BY MYELOID-DERIVED SUPPRESSOR CELLS
(2015)
Exosomes are a class of extracellular vesicles that have been shown to contribute to metastasis when derived from tumor cells. Myeloid-derived suppressor cells (MDSC) are an immature population of myeloid cells that ...
ROLE OF SALT BRIDGES IN GROEL ALLOSTERY
(2014)
Chaperonin GroEL facilitates protein folding with two stacked back-to-back, identical rings and the "lid", co-chaperonin GroES. The mis-folded/unfolded substrate protein (SP) adjusts the chaperonin cycling from an asymmetric ...
BIOPHYSICAL STUDIES OF THE MECHANISM OF CERAMIDE CHANNEL DESTABLIZATION BY BCL-XL IN APOPTOSIS AND THE USE OF RECTIFICATION TO PROBE THE STRUCTURE AND DYNAMICS OF A NOVEL ESCHERICHIA COLI CHANNEL
(2015)
Ceramide forms a novel type of channel in the mitochondrial outer membrane and these channels are involved the release of intermembrane space proteins from mitochondria, a decision-making step in the apoptotic process. An ...
Dihydropyrrole Formation During Sibiromycin Biosynthesis
(2015)
A description of pyrrolo[1,4]benzodiazepine (PBD) biosynthesis in actinomycetes is a prerequisite for engineering production of analogs with enhanced antitumor activity. Several proteins expected to synthesize the PBD’s ...
The role of sequence in the structure of self-assembling 3D DNA crystals
(2015)
DNA is a widely used biopolymer for the construction of nanoscale objects due to its programmability and structural predictability. DNA oligonucleotides can, however, exhibit a great deal of local structural diversity. DNA ...
Probing Allosteric Communication Between Disordered Surfaces in a Protein
(2015)
Molecular mechanisms of protein allostery are not well understood, particularly in those systems that undergo disorder to order transitions upon activation. BirA, an E.coli metabolic enzyme and transcriptional repressor, ...
A New Role for the CYT-18 N-Terminus and Three-Dimensional DNA Crystals as Vehicles for Biocatalysis
(2014)
The bifunctional Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (N. crassa mt TyrRS; CYT-18 protein) promotes the splicing of multiple group I introns by stabilizing the catalytically active intron structures. ...
EVALUATING IN VITRO AND IN VIVO LOOPING EFFICIENCIES OF ARTIFICIAL DNA-BINDING PROTEINS
(2014)
DNA looping plays an important role in gene regulation by increasing the local concentration of a transcriptional activator or repressor at its primary binding site. Several <italic>in vitro</italic> and <italic>in ...
Applications of 2,3-Diketoesters in Organic Synthesis and Stereoselective Transformations
(2014)
Dimethyldioxyrane oxidation of δ-hydroxy-α-diazo-β-ketoesters that are prepared by zinc triflate catalyzed Mukaiyama-aldol condensation of methyl diazoacetoacetates with aldehydes, occurred in quantitative ...