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Now showing items 21-30 of 52
PLASTICITY IN PROTEIN SEQUENCE-FUNCTION RELATIONSHIPS
(2021)
Allostery is defined as the functional regulation at one site in a protein by activity at a distant site. Because of the ubiquitous occurrence and diverse cellular roles of allosteric proteins, designing novel allosteric ...
Jet Production Cross Section Measurement In √ s = 5.02 Tev pp Collisions
(2021)
The study of jets offers insights into the nature of the basic partons composing matter, and enables further studies into the nature of the universe. This analysis presents the double-differential production cross section ...
Mechanistic Studies of Photochemical Reactions: Photoacid Generators, Photoreleaseable Protecting Groups, and Diarylnitrenium Ions
(2021)
The use of light to drive chemical reactions is becoming increasingly popular due to the enhanced spatial and temporal control provided. Because of this, it is important to understand how these photochemical transformations ...
Transient Infrared Absorption Studies of Molecular Super Rotors Prepared in a Tunable Optical Centrifuge
(2021)
In the work presented here, an ultrafast, angularly accelerating optical trap, called an optical centrifuge, rotationally excites gas-phase molecules such as N2O, CO, and CO2 to extremely high-J rotational levels with ...
Magnetism and superconductivity in topotactically modified transition metal chalcogenides
(2020)
Inspired by the structure of the simplest iron-based chalcogenide superconductor, FeSe, the class of tetrahedral transition metal chalcogenides (TTMCs) exhibit interesting chemical and physical properties due to its ...
High Affinity Host-Guest Pairs Enable In Vitro and In Vivo Sequestration of Drugs of Abuse
(2020)
Molecular containers of diverse structure and binding preferences has led to their incorporation in numerous applications such as drug solubilization, drug delivery, and drug sequestration. A detailed understanding of the ...
THE UNIQUE PROPERTIES OF BRANCHED K11/K48-LINKED POLYUBIQUITIN, AND THE PROTEASOMAL RECOGNITION OF (POLY)UBIQUITIN AND UBIQUITIN-LIKE SIGNALS BY RPN1
(2021)
Post-translational modification of substrates with ubiquitin (Ub) is an essential process across all eukaryotes, responsible for regulating a myriad of cellular pathways. Many aspects of ubiquitination are extensively ...
NOVEL PLATINUM COMPLEXES SUPPORTED BY SULFONATED CNN PINCER LIGANDS RELEVANT TO AEROBIC METHANE FUNCTIONALIZATION CHEMISTRY
(2021)
Mild and selective aerobic methane functionalization has always been a challenge. Shilov developed a PtII based system that has a potential to solve the problem, but the non-practical PtIV oxidant needs to be substituted ...
COMBINED CHEMICAL AND ENZYMATIC APPROACHES TO PROTEIN GLYCOSYLATION
(2021)
Glycosylation is a key post-translational modification of proteins and influences the structure and biological functions of proteins. Glycoproteins are significant in treating a variety of diseases and make up a large ...
Structural and Biophysical Characterization of Homo Sapiens RIOK2 in Complex with Selective Prostate Cancer Inhibitors and its Transition State Complex
(2021)
Homo sapiens Riok2 (HsRiok2) is an atypical, Ser/Thr protein kinase that has been implicated in a number of cancers, including Prostate Cancer. More recently, evidence has shown that HsRiok2 plays a biological role in the ...