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Now showing items 11-20 of 553
A GAS-INJECTION NEGATIVE ION SOURCE FOR ACCELERATOR MASS SPECTROMETRY
(2004-11-04)
Accelerator mass spectrometry is an ultra-sensitive isotopic analysis technique that allows for the determination of rare long-lived radionuclides such as radiocarbon. Historically, the technique has required that samples ...
Lipophilic G-Quadruplexes: Structural Studies, Post-Assembly Modification, and Covalent Capture
(2006-08-29)
New nanostructures and functional materials are built through the self-assembly of guanosine. Both the size and regiochemistry of these noncovalent structures are controlled. Lipophilic G-quadruplexes are further stabilized ...
Ultra-fast Dynamics of Small Molecules in Strong Fields
(2006-04-24)
Correlation detection techniques (image labeling, coincidence imaging, and joint variance) are developed with an image spectrometer capable of collecting charges ejected over 4\pi sr and a digital camera synchronized with ...
NMR studies of polyubiquitin chains: insights into structural basis of functional diversity
(2004-10-25)
Signaling by polyubiquitin (polyUb) chains mediates numerous cellular processes. All these processes involve the covalent modification of the substrate protein with a polyubiquitin chain that is itself formed by isopeptide ...
COMPARATIVE PROTEOMICS STUDIES OF SOLUBLE NUCLEAR PROTEINS OF DRUG SUSCEPTIBLE AND RESISTANT HUMAN BREAST CANCER MCF-7 CELLS
(2004-10-05)
Drug resistance is a major obstacle in cancer chemotherapy. Better understanding of the mechanisms of the drug resistance can help to improve clinical treatment and develop new drugs. Since most anticancer drugs target the ...
Investigation into the Driving Force Dependence of Excess Electron Transport in Duplex DNA
(2009)
The purpose of this dissertation is to investigate the driving force dependence of excess electron transport in deoxyribonucleic acid (DNA) using napthyl amines as electron donors.
The ability of DNA to act as a pathway ...
ELECTROCHEMICAL OXIDATION KINETICS OF HYDROGEN AND HIGHER HYDROCARBON FUELS ON SOLID OXIDE FUEL CELLS.
(2007-11-27)
Solid oxide fuel cells (SOFCs) are promising electrochemical energy converting devices due to their ability to use not only hydrogen but also hydrocarbons as a fuel. Although conventional SOFCs with Ni/YSZ anodes and ...
Efforts Toward Synthesis of Novel Analogs of the Bacterial Second-Messenger, c-di-GMP
(2009)
The formation of bacterial biofilms is a common mechanism for antibiotic resistance. It has been shown that bis-(3'-5')-cyclic dimeric guanosine monophosphate, c-di-GMP, plays a key role in bacterial biofilm formation; ...
Applications of Multiphoton Imaging Techniques To The Study Of Protein Interactions
(2009)
Several recent improvements in microscopy have been driven by advances in ultrafast laser technology. The goal of the research described in this dissertation was to develop noninvasive, optically based methods to measure ...
Synthesis of Magnetic Nanotubes as Magnetic Resonance Contrast Agents and Drug Carriers and the Study of Their Cytotoxicity
(2008-11-20)
The increasing interest in the medical application of nanotechnology has heightened the need for synthesizing nanoparticles with well-defined dimensions and multifunctionalities. Studies on template synthesis demonstrate ...