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Trapping Labile Adducts Formed Between an ortho-Quinone Methide and DNA
(2012)
Exogenously generated electrophiles are capable of alkylating DNA. If not repaired, the resulting DNA adducts can lead to mutations and either cancer or cell death. Electrophilic ortho-quinone methides (o-QM) are reactive ...
Alterations in the Primary Structures of Ribosomal Proteins in Acquired Drug Resistance
(2012)
Acquired drug resistance is a multifactorial process that is one of the major causes for cancer treatment failure. The anticancer drug, mitoxantrone, was recently determined to inhibit ribosome biogenesis. Changes in ...
MESOPOROUS SILICA NANOPARTICLES AS DRUG DELIVERY SYSTEMS AND DIAGNOSTIC TOOLS
(2011)
Micro- and nano-scale silica materials have recently gained attention due to their potential as biosensors, site-specific drug delivery systems and diagnostic tools. Accordingly, examples of the preparation and use of ...
The conformational landscape of RNA translational regulators and their potential as drug discovery targets
(2016)
RNA is an underutilized target for drug discovery. Once thought to be a passive carrier of genetic information, RNA is now known to play a critical role in essentially all aspects of biology including signaling, gene ...
QUANTITATIVE ASSESSMENT OF BIS(2-ETHYLHEXYL) PHTHALATE IN COMMONLY-CONSUMED FOODS AND ELUCIDATION OF ITS NATURAL COMPONENT IN STILTON CHEESE BY COMPOUND-SPECIFIC CARBON ISOTOPE ANALYSIS
(2013)
Bis(2-ethylhexyl) phthalate (DEHP) is classified as a "priority hazardous substance" by the European Union, a probable human carcinogen by the United States Environmental Protection Agency, and is a suspect human endocrine ...
DESIGN AND DEVELOPMENT OF THREE-DIMENSIONAL DNA CRYSTALS UTILIZING CGAA PARALLEL BASE PAIRED MOTIFS
(2013)
Three-dimensional (3D) DNA crystals hold great potential for various applications such as the development of molecular scaffolds for use in protein structure determination by x-ray crystallography. The programmability and ...
QUANTIFYING PARTICLE PROPERTIES FROM ION-MOBILITY MEASUREMENTS
(2012)
Nanoparticles have received considerable interest due to the wide variety of potential applications in biomedical, optical, and electronic fields. However, our capabilities for quantitatively charactering these materials, ...
Microfluidic Production of Polymeric Functional Microparticles
(2012)
This dissertation focuses on applying droplet-based microfluidics to fabricate new classes of polymeric microparticles with customized properties for various applications. The integration of microfluidic techniques with ...
DIRHODIUM CAPROLACTAMATE CATALYZED OXIDATIONS BY TERT-BUTYL HYDROPEROXIDE. FROM MECHANISMS TO NEW METHODOLOGIES
(2012)
Dirhodium caprolactamate, Rh<sub>2</sub>(cap)<sub>4</sub>, is a very efficient catalyst for the generation of the <italic>tert</italic>-butylperoxy radical from <italic>tert</italic>-butyl hydroperoxide, and the ...
Simulations of nonuniform fluids with long-ranged and short-ranged interactions
(2012)
The study of nonuniform fluids is of great importance in many areas of chemistry, biophysics,and materials science. Computer simulations of model systems have provided great insight into fundamental physical issues. We ...