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RNAs are essential components of biological pathways that result in human disease making them attractive therapeutic targets. Currently, NMR spectroscopy is the only high-resolution technique capable of probing RNA ...

Deoxyribonucleic acid (DNA) has been repurposed as a building block in the construction of nanoscale assemblies. The biocompatibility, stability, programmability, structural predictability, and ability to self-assemble ...

Ubiquitin (Ub) is a protein that serves several important functions in all eukaryotes. Its role involves post-translational modification of target proteins which results in signaling for cellular activities of various ...

Bacterial microcompartments (BMCs) are polyhedral, protein-based organelles present in a wide range of bacteria. This mode of compartmentalization is highly modular and can accommodate a wide range of chemistries within ...

RNAs are dynamic macromolecules that function as essential components of biological pathways that result in human disease, making them attractive therapeutic targets. Yet, RNA structural biology lags significantly behind ...

Bacterial biofilms, which are comprised of bacterial cells embedded in a thick extracellular polymeric substance (EPS), is a type of survival mechanism used by a variety of medically relevant bacteria to endure harsh ...

With the increasing accessibility of patient genome sequencing, causative mutations for rare genetic diseases are being uncovered at an unprecedented rate. Among these are disorders resulting from mutations in protein ...

Antibiotic resistance is a major health challenge globally. Therefore, there is the need for new antibiotics. Here, we screen compounds with new scaffolds using nuclear magnetic resonance (NMR) spectroscopy and identified ...