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STRUCTURAL STUDY OF THE EARLY SECRETORY PROTEIN B AND ATYPICAL RIO2 KINASE
(2015)
Mycobacterium tuberculosis, Mtb, is a successful pathogen that secretes variety of proteins to manipulate the host defense mechanisms and create a proper environment for its survival. The progression of the disease depends ...
PROTEOMIC CHARACTERIZATION OF EXOSOMES SHED BY MYELOID-DERIVED SUPPRESSOR CELLS
(2015)
Exosomes are a class of extracellular vesicles that have been shown to contribute to metastasis when derived from tumor cells. Myeloid-derived suppressor cells (MDSC) are an immature population of myeloid cells that ...
BIOPHYSICAL STUDIES OF THE MECHANISM OF CERAMIDE CHANNEL DESTABLIZATION BY BCL-XL IN APOPTOSIS AND THE USE OF RECTIFICATION TO PROBE THE STRUCTURE AND DYNAMICS OF A NOVEL ESCHERICHIA COLI CHANNEL
(2015)
Ceramide forms a novel type of channel in the mitochondrial outer membrane and these channels are involved the release of intermembrane space proteins from mitochondria, a decision-making step in the apoptotic process. An ...
Dihydropyrrole Formation During Sibiromycin Biosynthesis
(2015)
A description of pyrrolo[1,4]benzodiazepine (PBD) biosynthesis in actinomycetes is a prerequisite for engineering production of analogs with enhanced antitumor activity. Several proteins expected to synthesize the PBD’s ...
The role of sequence in the structure of self-assembling 3D DNA crystals
(2015)
DNA is a widely used biopolymer for the construction of nanoscale objects due to its programmability and structural predictability. DNA oligonucleotides can, however, exhibit a great deal of local structural diversity. DNA ...
Probing Allosteric Communication Between Disordered Surfaces in a Protein
(2015)
Molecular mechanisms of protein allostery are not well understood, particularly in those systems that undergo disorder to order transitions upon activation. BirA, an E.coli metabolic enzyme and transcriptional repressor, ...
Ligand-Linked Disorder-to-Order Transitions in Allosteric Communication
(2015)
Ligand-linked disorder-to-order transitions are integral to the function of numerous cellular proteins. Furthermore, these transitions can contribute to allosteric regulation, a principal mechanism controlling protein ...
The Core of Eukaryotic Ribosomal Protein uS19 Functions as a Pivot Point Enhancing Eukaryotic Ribosome Flexibility
(2015)
While most ribosomal elements are highly conserved in the three domains of life, over the course of evolution, significant differences have emerged as ribosomes have been subjected to different types of selective pressure. ...
USE OF 2-DEOXYFLAVIN MONONUCLEOTIDE TO PROBE SUBSTRATE-FLAVIN INTERACTIONS WITHIN IODOTYROSINE DEIODINASE
(2015)
The catalytic versatility of flavins encompasses the ability to catalyze one and two electron redox processes as well as dioxygen activation. In flavoenzymes, protein-cofactor interactions modulate flavin chemistry enabling ...
Epigenetics of Neurodegeneration: Quantification of Histone Deacetylase Isoforms and Post-translational Modifications of Histones in Alzheimer’s Disease
(2015)
Histone post-translational modifications have been implicated in many biological functions and diseases and serve an important role in epigenetic regulation of gene expression. Aberrant modulations in histone post-translational ...