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Selective Delivery of a Quinone Methide Precursor by Peptide Nucleic Acids
Quinone methides (QMs) are electrophilic intermediates that can be generated in vivo to alkylate DNA and function as anti-cancer drugs. Previously, DNA-QM conjugates have shown the ability to selectively deliver a QM to ...
REVERSIBLE QUINONE METHIDE ALKYLATION OF DNA
Alkylation of DNA has been found to cause cancer and also to serve as its treatment. Quinone methides (QMs) are highly electrophilic molecules implicated in numerous metabolism processes. Studies of QM's reversible ...