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Investigation into the Driving Force Dependence of Excess Electron Transport in Duplex DNA
(2009)
The purpose of this dissertation is to investigate the driving force dependence of excess electron transport in deoxyribonucleic acid (DNA) using napthyl amines as electron donors.
The ability of DNA to act as a pathway ...
Efforts Toward Synthesis of Novel Analogs of the Bacterial Second-Messenger, c-di-GMP
(2009)
The formation of bacterial biofilms is a common mechanism for antibiotic resistance. It has been shown that bis-(3'-5')-cyclic dimeric guanosine monophosphate, c-di-GMP, plays a key role in bacterial biofilm formation; ...
Discrete and Polymeric Complexes Comprising Bis-nor-seco-CB[10] and Oligoammonium Ions
(2009)
ABSTRACT
Title of Document: DISCRETE AND POLYMERIC COMPLEXES COMPRISING BIS-NOR-SECO-CB[10] AND OLIGOAMMONIUM IONS
Regan C. Nally, Ph.D., 2009
Directed By: Professor Lyle D. Isaacs
Department of Chemistry and ...
Synthetic Ion Channels From Lipophilic Guanosine Derivatives
(2009)
Synthetic ion channels and pores not only represent models of natural transmembrane ion channels, but also demonstrate their potential applications in the areas of drug delivery, biosensors, antimicrobial agents and other ...
PALLADIUM-CATALYZED ALLYLIC-ARYLATION: MECHANISTIC STUDIES AND APPLICATION TO THE TOTAL SYNTHESIS OF (+/-)-7-DEOXYPANCRATISTATIN DERIVATIVES
(2009)
Palladium-catalyzed carbon-carbon bond formation is one of the most widely used reactions for the synthesis of biologically active substances. The DeShong group has demonstrated that hypervalent silicates can be employed ...
REVERSIBLE QUINONE METHIDE ALKYLATION OF DNA
(2009)
Alkylation of DNA has been found to cause cancer and also to serve as its treatment. Quinone methides (QMs) are highly electrophilic molecules implicated in numerous metabolism processes. Studies of QM's reversible ...
Visible Light Photorelease of Carboxylate Anions by Mediated Photoinduced Electron Transfer to Pyridinium-based Protecting Groups
(2009)
The use of sensitized photoinduced electron transfer (PET) to trigger release of redox-active photoremovable protecting groups (PRPGs) allows a broad range of chromophores to be selected that absorb in difference wavelength ...
NEW LIGAND MOTIFS FOR PLATINUM-BASED `SHILOV CHEMISTRY' AND DETOURS INTO BASIC ORGANOMETALLIC RESEARCH
(2009)
The C-H activation reaction at cationic platinum centers utilizing chelating aromatic N-type ligands has been widely studied in TFE (trifluoroethanol): a weakly coordinating solvent. In our laboratory, recent studies ...
COMPLEX SELF-SORTING SYSTEMS
(2009)
Over the past century scientists have taken a reductionist approach towards much of the physical and biological sciences. More recently scientists have become interested in constructing complex systems from their components ...
USING "SMALL" MOLECULES AS TRANSMEMBRANE ANION TRANSPORTERS
(2009)
Functional, "small" molecule anion transporters have been identified and developed from natural products and synthetic organic compounds. The major discoveries include the design of a transmembrane Cl<super>-</super> ...