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Using Energy Landscape Theory to Uncover the Organization of Conformational Space of Proteins in Their Native States.
The functional motions of proteins navigate on rugged energy landscapes. Hence, mapping of these multidimensional landscapes into lower dimensional manifolds is imperative for gaining deeper insights into the functional ...
Experimental, Computational and, Theoretical Analysis of the GroEL/GroES Catalytic Cycle
The GroEL/GroES system is among the best characterized molecular chaperonins, having been the focus of numerous studies since its discovery just over 40 years ago. There are several aspects of the chaperonin's catalytic ...
Jamming effects in glasses and biopolymers
In this dissertation, jamming effects in highly packed systems are studied in two specific materials: glasses and biopolymers in cellular environments. Suspensions consisting of highly charged colloids, which are well-known ...
The Yin and Yang of Amyloids: Insights from alpha-Synuclein and the Pmel17 Repeat Domain
While amyloidogenic proteins are commonly associated with human diseases such as Alzheimer's and Parkinson's disease, it is intriguing that amyloid fibrils also are utilized for essential biological processes. A key ...
BIOPHYSICAL STUDIES OF UBIQUITIN: FROM FOLDING TO PROTEIN ENGINEERING
The signaling protein ubiquitin is known for its ubiquity — existing in nearly all cel- lular compartments, holding a prominent role in major cellular signaling pathways and serving as a model system for protein folding. ...