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DESIGN AND SYNTHESIS OF AN ELECTRON RICH QUINONE METHIDE PRECURSOR FOR SEQUENCE -DIRECTED ALKYLATION OF DNA
(2012)
Quinone methides (QM) can be delivered to alklyate specific sites with a single strand DNA through target promoted alkylation. Previous experimental results indicated that alkylation by DNA-QM self-adduct was too slow for ...
Structural Studies of the Atypical Rio2 Kinase and N-Acetylglutamate Synthase
(2011)
Rio2 is required for small subunit ribosomal RNA (rRNA) maturation. It is specifically involved in site D cleavage of the 20S rRNA to produce the mature 18S rRNA. Loss of Rio2p is lethal and a decrease of Rio2p activity ...
STRUCTURAL STUDY OF THE EARLY SECRETORY PROTEIN B AND ATYPICAL RIO2 KINASE
(2015)
Mycobacterium tuberculosis, Mtb, is a successful pathogen that secretes variety of proteins to manipulate the host defense mechanisms and create a proper environment for its survival. The progression of the disease depends ...
Dihydropyrrole Formation During Sibiromycin Biosynthesis
(2015)
A description of pyrrolo[1,4]benzodiazepine (PBD) biosynthesis in actinomycetes is a prerequisite for engineering production of analogs with enhanced antitumor activity. Several proteins expected to synthesize the PBD’s ...
Applications of 2,3-Diketoesters in Organic Synthesis and Stereoselective Transformations
(2014)
Dimethyldioxyrane oxidation of δ-hydroxy-α-diazo-β-ketoesters that are prepared by zinc triflate catalyzed Mukaiyama-aldol condensation of methyl diazoacetoacetates with aldehydes, occurred in quantitative ...
USE OF 2-DEOXYFLAVIN MONONUCLEOTIDE TO PROBE SUBSTRATE-FLAVIN INTERACTIONS WITHIN IODOTYROSINE DEIODINASE
(2015)
The catalytic versatility of flavins encompasses the ability to catalyze one and two electron redox processes as well as dioxygen activation. In flavoenzymes, protein-cofactor interactions modulate flavin chemistry enabling ...
STRUCTURAL AND BIOLOGICAL STUDIES OF ATYPICAL RIO1 KINASE
(2011)
Rio1 kinase is an atypical protein kinase that is essential for the proper maturation of the 40S subsunit during ribosome biogenesis. Ribosome biogenesis is linked to cell cycle progression and studies have shown that the ...
Polymorphism of Cyclic Dinucleotides
(2015)
Cyclic dinucleotides such as cyclic dimeric guanosine monophosphate (c-di-GMP,) cyclic dimeric adenosine monophosphate (c-di-AMP) and cyclic guanosine-adenosine monophosphate (cGAMP) are found in both prokaryotes and ...
Silencing bacteria with small molecules
(2014)
Quorum sensing (QS) is a phenomenon in bacteria where the accumulation of extracellular signaling molecules (autoinducers, AIs), which enable bacterial cells to sense neighboring cells (population density), reaches certain ...
Development of Magnetic Nanoparticle-based Enrichment Techniques and Mass Spectrometry Methods for Quantification of the Clinical Biomarker Cardiac Troponin I
(2016)
Human cardiac troponin I (cTnI) in serum is a well-known clinical biomarker for cardiac tissue damage and is used for diagnosing myocardial infarction. Unfortunately, commercial cTnI immunoassays from different manufacturers ...