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Rio2 is required for small subunit ribosomal RNA (rRNA) maturation. It is specifically involved in site D cleavage of the 20S rRNA to produce the mature 18S rRNA. Loss of Rio2p is lethal and a decrease of Rio2p activity ...

Type IIA topoisomerases are essential, universally conserved proteins that modify DNA topology by passing one segment of duplex DNA (the transfer, or T-segment) through a transient double strand break in a second segment ...

The variety of DNA loops formed by a protein such as Lac Repressor (LacI), predicted to populate multiple loop topologies and geometries, increases the uncertainty of models that have not been experimentally verified. We ...

Nucleolar Essential Protein 1 (Nep1) is required for small subunit (SSU) ribosomal RNA (rRNA) maturation and is mutated in Bowen-Conradi Syndrome. Although yeast (Saccharomyces cerevisiae) Nep1 interacts with a consensus ...

Rio1 kinase is an atypical protein kinase that is essential for the proper maturation of the 40S subsunit during ribosome biogenesis. Ribosome biogenesis is linked to cell cycle progression and studies have shown that the ...

As new disease biomarkers such as cancer-linked microRNAs are discovered, the need for new strategies for the detection of these disease biomarkers at isothermal conditions will increase. The junction probe (JP) technology ...

Human Holocarboxylase Synthetase (HCS) transfers the vitamin biotin to the biotin carboxyl carrier protein (BCCP) domains of five biotin-dependent carboxylases. There are two major forms of HCS present in mammalian cells, ...

Mechanosensation is the ability to respond to mechanical stimuli. It is present in many organisms. In Escherichia coli (E. coli), mechanosensation manifests in two membrane channels, the large mechanosensitive channel ...

While amyloidogenic proteins are commonly associated with human diseases such as Alzheimer's and Parkinson's disease, it is intriguing that amyloid fibrils also are utilized for essential biological processes. A key ...