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EPIGENETICS TUNE CHROMATIN MECHANICS, A COMPUTATIONAL APPROACH
The base unit of DNA packaging in eukaryotes, the nucleosome, is adaptively modified for epigenetic control. Given the vast chemical space of chromatin and complexity of signaling and expression, much of our knowledge about ...
STRUCTURAL CHARACTERIZATION OF THE PRMT5-RIOK1-NUCLEOLIN COMPLEX
Protein methylation is one of the most important protein post-translational modifications. Protein arginine methyltransferase 5 (PRMT5) catalyzes the mono- and symmetric dimethylation of arginine residues of a wide range ...