Now showing items 1-6 of 6
PRINCIPLES OF COMPLEX POLYUBIQUITIN SIGNALING, THE STRUCTURAL BASIS FOR UBIQUITIN-UBISTATIN INTERACTIONS, AND NOVEL ASSAYS FOR THE CHARACTERIZATION OF DEUBIQUITINASES
Ubiquitination is the most versatile and is certainly one of the most difficult post-translation modifications to understand in eukaryotic life. In the process of ubiquitination the C-terminus of ubiquitin (Ub), a small ...
DESIGN AND DEVELOPMENT OF THREE-DIMENSIONAL DNA CRYSTALS UTILIZING CGAA PARALLEL BASE PAIRED MOTIFS
Three-dimensional (3D) DNA crystals hold great potential for various applications such as the development of molecular scaffolds for use in protein structure determination by x-ray crystallography. The programmability and ...
NEW CHEMICAL TOOLS TO INVESTIGATE RNA FUNCTIONS
Ribonucleic acid (RNA), as one of the essential macromolecules of life, plays an active role in gene regulation, catalysis, and signaling because of its ability to adopt complex 3D structures that can exist in multiple ...
CHARACTERIZATION OF BRANCHED HISTIDINE-LYSINE POLYPEPTIDES USED FOR NUCLEIC ACID DELIVERY AND THEIR COMPLEXES WITH DNA AND SMALL INTERFERING RNA.
DNA and siRNA must be packaged for protection prior to transfection in vivo when they are administered to humans or other animals. Dr. A. J. Mixson's laboratory at the University of Maryland, Baltimore Medical School has ...
DEVELOPMENT OF A PROTEOMIC STRATEGY FOR ANALYSIS OF PLASMA MEMBRANE PROTEINS
Plasma membrane (PM) proteins play crucial roles in cell signaling and communications, and they are the targets of more than two thirds of drugs currently under development. Studies on changes in protein content, quantity ...
An Analysis of the Stability, Aggregation Propensity, and Negative Cooperativity of the Escherichia coli Chaperonin GroEL
Since the discovery of chaperonin GroEL and co-chaperonin GroES, there has been a deluge of literature investigating many aspects of the system. Substrate proteins are protected from aggregation through a cycle of capture, ...