Now showing items 1-10 of 26
Mechanistic investigations of stoichiometric and catalytic Pt-mediated oxidative functionalization at a proximal boron center
The focus of the work detailed in this dissertation is the investigation of mechanism and catalytic applications of Pt complexes supported by novel anionic di(2-pyridyl)borate ligands. It was found that oxidation of ...
CATANIONIC SURFACTANT VESICLES: TECHNOLOGY FOR VACCINE DEVELOPMENT AND TARGETED DRUG DELIVERY APPLICATIONS
Catanionic surfactant vesicles have gained attention due to their structural similarities to liposomes and their robust properties in biological media. Catanionic vesicles are formed from oppositely charged surfactants ...
PRINCIPLES OF COMPLEX POLYUBIQUITIN SIGNALING, THE STRUCTURAL BASIS FOR UBIQUITIN-UBISTATIN INTERACTIONS, AND NOVEL ASSAYS FOR THE CHARACTERIZATION OF DEUBIQUITINASES
Ubiquitination is the most versatile and is certainly one of the most difficult post-translation modifications to understand in eukaryotic life. In the process of ubiquitination the C-terminus of ubiquitin (Ub), a small ...
CHEMICAL FUNCTIONALIZATION OF CARBON NANOTUBES FOR CONTROLLED OPTICAL, ELECTRICAL AND DISPERSION PROPERTIES
A carbon nanotube is a graphitic sheet, rolled into a one-dimensional, hollow tube. This structure provides certain individual nanotubes with high conductivity and near-infrared optical activity. These properties are not ...
COMPUTER SIMULATIONS OF PROTEIN FOLDING
Understanding how proteins fold and interact with each other is key to understanding virtually all biological processes. Recent advances in computer power and modeling techniques make it possible to study proteins and other ...
Book of Abstracts: 8th International Symposium on Macrocyclic and Supramolecular Chemistry
This pdf file is the finalized version of the book of abstracts for the 8th International Symposium on Macrocyclic Chemistry held in Arlington, Virginia, USA from July 7-11, 2013
QUANTITATIVE ASSESSMENT OF BIS(2-ETHYLHEXYL) PHTHALATE IN COMMONLY-CONSUMED FOODS AND ELUCIDATION OF ITS NATURAL COMPONENT IN STILTON CHEESE BY COMPOUND-SPECIFIC CARBON ISOTOPE ANALYSIS
Bis(2-ethylhexyl) phthalate (DEHP) is classified as a "priority hazardous substance" by the European Union, a probable human carcinogen by the United States Environmental Protection Agency, and is a suspect human endocrine ...
DESIGN AND DEVELOPMENT OF THREE-DIMENSIONAL DNA CRYSTALS UTILIZING CGAA PARALLEL BASE PAIRED MOTIFS
Three-dimensional (3D) DNA crystals hold great potential for various applications such as the development of molecular scaffolds for use in protein structure determination by x-ray crystallography. The programmability and ...
NEW CHEMICAL TOOLS TO INVESTIGATE RNA FUNCTIONS
Ribonucleic acid (RNA), as one of the essential macromolecules of life, plays an active role in gene regulation, catalysis, and signaling because of its ability to adopt complex 3D structures that can exist in multiple ...
CHARACTERIZATION OF BRANCHED HISTIDINE-LYSINE POLYPEPTIDES USED FOR NUCLEIC ACID DELIVERY AND THEIR COMPLEXES WITH DNA AND SMALL INTERFERING RNA.
DNA and siRNA must be packaged for protection prior to transfection in vivo when they are administered to humans or other animals. Dr. A. J. Mixson's laboratory at the University of Maryland, Baltimore Medical School has ...