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Trapping Labile Adducts Formed Between an ortho-Quinone Methide and DNA
Exogenously generated electrophiles are capable of alkylating DNA. If not repaired, the resulting DNA adducts can lead to mutations and either cancer or cell death. Electrophilic ortho-quinone methides (o-QM) are reactive ...
DIRHODIUM CAPROLACTAMATE CATALYZED OXIDATIONS BY TERT-BUTYL HYDROPEROXIDE. FROM MECHANISMS TO NEW METHODOLOGIES
Dirhodium caprolactamate, Rh<sub>2</sub>(cap)<sub>4</sub>, is a very efficient catalyst for the generation of the <italic>tert</italic>-butylperoxy radical from <italic>tert</italic>-butyl hydroperoxide, and the ...
DESIGN AND SYNTHESIS OF AN ELECTRON RICH QUINONE METHIDE PRECURSOR FOR SEQUENCE -DIRECTED ALKYLATION OF DNA
Quinone methides (QM) can be delivered to alklyate specific sites with a single strand DNA through target promoted alkylation. Previous experimental results indicated that alkylation by DNA-QM self-adduct was too slow for ...
Characterization and Investigation of Benzylic Carbenium Ion and Carbanion Ion-Diradical Intermediates With 3,5-Disubstituted (pi)-Donors/Acceptors
High-spin magnetic materials have been based on monomeric units that contain metals. Far less research has been done to develop and characterize alternative high-spin building blocks consisting of mostly organic subunits. ...