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Trapping Labile Adducts Formed Between an ortho-Quinone Methide and DNA
(2012)
Exogenously generated electrophiles are capable of alkylating DNA. If not repaired, the resulting DNA adducts can lead to mutations and either cancer or cell death. Electrophilic ortho-quinone methides (o-QM) are reactive ...
Alterations in the Primary Structures of Ribosomal Proteins in Acquired Drug Resistance
(2012)
Acquired drug resistance is a multifactorial process that is one of the major causes for cancer treatment failure. The anticancer drug, mitoxantrone, was recently determined to inhibit ribosome biogenesis. Changes in ...
QUANTITATIVE ASSESSMENT OF BIS(2-ETHYLHEXYL) PHTHALATE IN COMMONLY-CONSUMED FOODS AND ELUCIDATION OF ITS NATURAL COMPONENT IN STILTON CHEESE BY COMPOUND-SPECIFIC CARBON ISOTOPE ANALYSIS
(2013)
Bis(2-ethylhexyl) phthalate (DEHP) is classified as a "priority hazardous substance" by the European Union, a probable human carcinogen by the United States Environmental Protection Agency, and is a suspect human endocrine ...
QUANTIFYING PARTICLE PROPERTIES FROM ION-MOBILITY MEASUREMENTS
(2012)
Nanoparticles have received considerable interest due to the wide variety of potential applications in biomedical, optical, and electronic fields. However, our capabilities for quantitatively charactering these materials, ...
Microwave-Supported Acid Hydrolysis for Proteomics
(2012)
Our goal is to develop, optimize and demonstrate workflows that incorporate rapid Asp-selective chemical proteolysis into proteomic studies of complex mixtures. This can be further divided into several specific aims. The ...
Metal Sulfides for High Performance Lithium Ion and Sodium Ion Battery Anodes
(2015)
The research described in this dissertation aims to develop facile synthetic routes to fabricate carbon coated metal sulfides (SnS, SnS2, MoS2) with sophisticated nanostructure to achieve high capacity and long cycle life ...
Investigating the Mechanism of Phenol Photooxidation by Humic Substances
(2014)
It is well established that organic pollutants such as phenols are degraded in the presence of chromophoric dissolved organic matter (CDOM) and sunlight in natural waters. Early work attributed the photochemical loss of ...
Ionics and Electrochemical Reactions in 1D and 3D Crosslinked Porous Electrodes
(2015)
Lithium ion batteries are a critical component enabling many modern technologies, including portable electronics, hybrid electric vehicles and more. While interest in nanomaterials for lithium ion batteries has been growing ...
Epigenetics of Neurodegeneration: Quantification of Histone Deacetylase Isoforms and Post-translational Modifications of Histones in Alzheimer’s Disease
(2015)
Histone post-translational modifications have been implicated in many biological functions and diseases and serve an important role in epigenetic regulation of gene expression. Aberrant modulations in histone post-translational ...
A Deuterium Labeling Method for the Characterization of (Chromophoric) Dissolved Organic Matter Using Ultrahigh Resolution Electrospray Ionization Mass Spectrometry
(2015)
Dissolved organic matter (DOM) is a complex ensemble of naturally occurring organic compounds found in virtually all aquatic environments. The overwhelming diversity of DOM makes it extremely difficult to understand the ...