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Branching activity switches actin network between connected and fragmented states in a myosin-dependent manner
(2021)
Actin networks rely on nucleation mechanisms to generate new filaments because de-novo nucleation is kinetically disfavored. Branching nucleation of actin filaments by Arp2/3, in particular, is critical for actin ...
ELECTROCHEMICAL PROTECTION OF LITHIUM METAL ANODE IN LITHIUM-SULFUR BATTERIES AND BEYOND
(2020)
With the growing demand of advanced energy storage devices that have high energy density and high power density to power electric vehicles and electrical grid, scientists and engineers are exploring technologies beyond ...
DEVELOPMENT OF SINGLE-CELL MASS SPECTROMETRY TOOLS TO INVESTIGATE METABOLIC REORGANIZATION DURING EARLY EMBRYOGENESIS
(2020)
Measurement of metabolism in single cells holds the potential to advance our understanding of fundamental biological processes during cell differentiation and development. However, to characterize the metabolic state of ...
TRANSIENT SPECTROSCOPY AND DYNAMICS OF OPTICALLY CENTRIFUGED MOLECULES
(2020)
This dissertation investigates the behavior of molecules with extreme amounts of rotational energy and oriented angular momentum. The molecules studied in this thesis are prepared in an optical centrifuge and are studied ...
MECHANISTIC STUDY AND THE DESIGN OF IRON-CATALYZED MULTI-COMPONENT CROSS-COUPLING REACTION
(2021)
Cross-coupling reactions (CCRs) are one of the most versatile methods for the formation of C-C bonds. Traditionally, palladium and nickel are broadly used as the catalyst in this type of transformation. However, due to the ...
CHARACTERIZATION OF THE STRUCTURE AND BINDING OF BRANCHED K6/K48-LINKED AND BRANCHED K6/63-LINKED POLYUBIQUITIN CHAINS
(2021)
Ubiquitin (Ub) is an important post-translational protein modifier in eukaryotes. Post-translational modification with Ub is an essential process for eukaryotic cellular signaling including protein degradation, DNA repair, ...
RAPID HEATING AND CHEMICAL SPECIATION CHARACTERIZATION FOR COMBUSTION PERFORMANCE ANALYSIS OF METALLIZED, NANOSCALE THERMITES AND PVDF BOUND SOLID PROPELLANT COMPOSITIONS
(2021)
Energetic materials research focuses on performance analysis of cost-effective solid materials which safely, precisely, and efficiently transitions stored chemical potential energy to kinetic energy at a rate throttled ...
Molecular Simulation and Spectroscopy of a Strong Multipolar Fluid
(2021)
Acetonitrile (CH3CN) is a small, aprotic molecule. The apparent simplicity of this species belies great complexity in its organization and dynamics in the liquid state. Additionally, at silica surfaces, liquid acetonitrile ...
EMERGENT NETWORK ORGANIZATION IN LINEAR AND DENDRITIC ACTIN NETWORKS REVEALED BY MECHANOCHEMICAL SIMULATIONS
(2021)
Cells employ networks of filamentous biopolymers to achieve shape changes and exert migratory forces. As the networks offer structural integrity to a cell, they are referred to as the cytoskeleton. Actin is an essential ...
INVESTIGATION OF ORDERED POROUS MATERIALS FOR LITHIUM AND MAGNESIUM IONS ELECTROCHEMICAL ENERGY STORAGE
(2021)
As portable electronics and electric vehicles become a more integral part of everyday life, rechargeable electrical energy storage devices (batteries) capable of providing greater energy and power densities will soon be ...