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STRUCTURAL STUDY OF THE EARLY SECRETORY PROTEIN B AND ATYPICAL RIO2 KINASE
Mycobacterium tuberculosis, Mtb, is a successful pathogen that secretes variety of proteins to manipulate the host defense mechanisms and create a proper environment for its survival. The progression of the disease depends ...
Dihydropyrrole Formation During Sibiromycin Biosynthesis
A description of pyrrolo[1,4]benzodiazepine (PBD) biosynthesis in actinomycetes is a prerequisite for engineering production of analogs with enhanced antitumor activity. Several proteins expected to synthesize the PBD’s ...
USE OF 2-DEOXYFLAVIN MONONUCLEOTIDE TO PROBE SUBSTRATE-FLAVIN INTERACTIONS WITHIN IODOTYROSINE DEIODINASE
The catalytic versatility of flavins encompasses the ability to catalyze one and two electron redox processes as well as dioxygen activation. In flavoenzymes, protein-cofactor interactions modulate flavin chemistry enabling ...
Polymorphism of Cyclic Dinucleotides
Cyclic dinucleotides such as cyclic dimeric guanosine monophosphate (c-di-GMP,) cyclic dimeric adenosine monophosphate (c-di-AMP) and cyclic guanosine-adenosine monophosphate (cGAMP) are found in both prokaryotes and ...