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Selective Delivery of a Quinone Methide Precursor by Peptide Nucleic Acids
Quinone methides (QMs) are electrophilic intermediates that can be generated in vivo to alkylate DNA and function as anti-cancer drugs. Previously, DNA-QM conjugates have shown the ability to selectively deliver a QM to ...
Target Alkylation of Single and Double Strand DNA by Peptide Nucleic Acids
Quinone methides (QMs) generated in vivo can alkylate DNA and function as anti-cancer drugs. Delivery of QMs to target DNA is necessary to reduce the side effects caused by indiscriminate reaction. Previous, DNA was ...