Browsing Chemistry & Biochemistry by Title
Now showing items 36-55 of 553
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Barcoded Silica Nanotubes for Bioanalysis
(2007-09-25)Analysis of the chemical/biological species involved in health care is the most important step for diseases diagnosis and new drug screening. Barcoded nano/microparticles are attracting more and more interest for detection ... -
Barrier Heights and Diffusion Coefficients in Protein Folding
(2007-08-03)A widely held view with respect to the folding of single-domain proteins is that they are two-state. In other words, it is seemingly sufficient to invoke just two thermodynamic macrostates - folded and unfolded - to explain ... -
Benzoyl-CoA Reductase: A Biological Birch Reduction
(2003-12-08)Benzoyl-CoA reductase, isolated from the anaerobic bacterium Thauera aromatica, catalyzes the ATP-dependent, two-electron reduction of the aromatic ring of benzoyl-CoA. A Birch-like mechanism, which involves two separate ... -
Bimetallic Nanoparticles for Advanced Energy Conversion Technologies
(2015)The increased demand for a more sustainable energy infrastructure has spurred the development of innovative energy conversion processes and devices, such as the proton exchange membrane fuel cell (PEMFC). PEMFCs are highly ... -
BIOCHEMICAL AND BIOLOGICAL CHARACTERIZATION OF THREE DNA REPAIR ENZYMES IN DEINOCOCCUS RADIODURANS
(2009)The Gram positive bacterium Deinococcus radiodurans is able to withstand acute doses of gamma rays that can cause hundreds of double-strand breaks per genome. In proposed double-stand break repair pathways, however, some ... -
BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF NUSG PARALOG LOAP
(2021)The NusG family of transcription factors is the only universally conserved family of transcription elongation regulators in all three domains of life. NusG proteins exert ubiquitous genetic regulatory effects by reversibly ... -
Biochemical characterization of the Minichromosome maintenance (MCM) helicase from Methanothermobacter thermautotrophicus
(2009)DNA replication requires coordination of numerous proteins to duplicate genetic information in a precise and timely manner. One of the key players in replication is the replicative helicase that unwinds the duplex DNA to ... -
Biochemical characterizations of extracellular vesicles shed by vegetative and sporulating Bacillus subtilis
(2015)Sporulation of Bacilli is a developmental process that provides long-term viability in unfavorable environments. Recently, biogenesis of extracellular vesicles (EVs) from Bacilli has also been reported to participate in ... -
BIOLOGICAL CHARACTERIZATION OF TWO PUTATIVE DNA METABOLISM ENZYMES IN DEINOCOCCUS RADIODURANS
(2014)HerA proteins are members of the FtsK-HerA superfamily of P-loop ATPases. FtsK is a bacterial protein that translocates double-stranded DNA during cell division. In archaea, herA is an essential gene that encodes an enzyme ... -
Bioorganic Chemistry of Prodigiosenes: Anion Transport, Basicity, Conformation and G-Quadruplex DNA Binding
(2015)Naturally occurring prodigiosenes are produced by microorganisms such as Streptomyces and Serratia marcescens. Prodigiosenes are fascinating for their wide range of biological activities in the form of anti-cancer, ... -
Bioorganic Chemistry of Sphingolipids: Pore Formation and Anion Transport
(2011)Ceramide is an amphiphilic natural product that plays important roles in multiple cellular processes. Ceramide also is known to self-assemble into transmembrane pores under physiologically relevant concentrations. In order ... -
Biophysical and Structural Characterization of the Parallel-Stranded d(CGA) Triplet Repeat Motif
(2022)Deoxyribonucleic acid (DNA) has been repurposed as a building block in the construction of nanoscale assemblies. The biocompatibility, stability, programmability, structural predictability, and ability to self-assemble ... -
BIOPHYSICAL STUDIES OF THE MECHANISM OF CERAMIDE CHANNEL DESTABLIZATION BY BCL-XL IN APOPTOSIS AND THE USE OF RECTIFICATION TO PROBE THE STRUCTURE AND DYNAMICS OF A NOVEL ESCHERICHIA COLI CHANNEL
(2015)Ceramide forms a novel type of channel in the mitochondrial outer membrane and these channels are involved the release of intermembrane space proteins from mitochondria, a decision-making step in the apoptotic process. An ... -
BIOPHYSICAL STUDIES OF UBIQUITIN: FROM FOLDING TO PROTEIN ENGINEERING
(2021)The signaling protein ubiquitin is known for its ubiquity — existing in nearly all cel- lular compartments, holding a prominent role in major cellular signaling pathways and serving as a model system for protein folding. ... -
Book of Abstracts: 8th International Symposium on Macrocyclic and Supramolecular Chemistry
(2013-07-07)This pdf file is the finalized version of the book of abstracts for the 8th International Symposium on Macrocyclic Chemistry held in Arlington, Virginia, USA from July 7-11, 2013 -
Branching activity switches actin network between connected and fragmented states in a myosin-dependent manner
(2021)Actin networks rely on nucleation mechanisms to generate new filaments because de-novo nucleation is kinetically disfavored. Branching nucleation of actin filaments by Arp2/3, in particular, is critical for actin ... -
Bringing New Chemistry to Guanosine Hydrogels
(2020)Molecular self-assembly is a powerful method to construct functional materials such as supramolecular hydrogels. Hydrogels contain mostly water but show solid-like rheology. Nucleosides and nucleotides contain rich recognition ... -
Building Block Approach to the Synthesis of a Cucurbit[7]uril Derivative Bearing Sulfonate Functional Groups
(2014)Low aqueous solubility prevents 40-70% of new pharmaceutical agents from reaching their full potential. The use of molecular containers as solubilizing agents is one solution currently under development. Chapter 1 introduces ... -
Building Block Synthesis and Recognition Properties of Cucurbit[n]uril (n = 7, 8) Derivatives
(2015)Molecular containers have been a topic of interest for chemists since the discovery of crown ethers and their molecular recognition properties in the late 1960’s. Since then, the field of molecular containers has expanded ... -
C-DI-GMP SIGNALLING IN BACTERIA-NEW OPPORTUNITIES FOR THE DEVELOPMENT OF ANTI-BIOFILM DRUGS
(2014)Bacterial infections are becoming more difficult to treat, due to the emergence of resistance strains to almost every antibiotic. Most bacteria that infect humans to cause diseases are biofilm forming bacteria and it has ...