Browsing Chemistry & Biochemistry by Title
Now showing items 412-431 of 553
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REVEALING THE STRUCTURAL AND FUNCTIONAL PROPERTIES OF NON-CANONICAL K6-LINKED POLYUBIQUITIN CHAINS.
(2017)Ubiquitin is an important protein modifier in eukaryotes, which tags the proteins and signals them to different pathways in the cell. It has been shown that polyubiquitin chains of different linkages act as distinct cellular ... -
REVERSIBLE QUINONE METHIDE ALKYLATION OF DNA
(2009)Alkylation of DNA has been found to cause cancer and also to serve as its treatment. Quinone methides (QMs) are highly electrophilic molecules implicated in numerous metabolism processes. Studies of QM's reversible ... -
Rh(II) catalyzed reactions of C-H insertion and oxonium ylide generation
(2011)Catalysis of metal carbene transformations with selected dirhodium(II) catalysts is a useful technology for constructing complex polycycles via intramolecular cyclopropanation, C-H insertion, and ylide derived reactions ... -
Rhodium(II)-Stabilized Vinylcarbenes: Synthetic Applications in Ylide, Cyclopropanation, and C-H Insertion Reactions
(2006-12-07)A previously unknown cascade reaction in which two units of a rhodium(II)-stabilized vinylcarbene obtained from methyl trans-styryldiazoacetate react with benzylideneaniline is described; the products of the cascade reaction ... -
The Ribosome and Beyond: Understanding the role of translational fidelity in rare genetic disorders
(2022)With the increasing accessibility of patient genome sequencing, causative mutations for rare genetic diseases are being uncovered at an unprecedented rate. Among these are disorders resulting from mutations in protein ... -
A Ring with a Spin : Superfluidity in a toroidal Bose-Einstein condensate
(2011)Superfluidity is a remarkable phenomenon. Superfluidity was initially characterized by flow without friction, first seen in liquid helium in 1938, and has been studied extensively since. Superfluidity is believed to be ... -
The role of charge in solvation at liquid/liquid interfaces
(2005-05-27)This dissertation describes the development and characterization of new surfactants, dubbed "molecular rulers," that provide an upper limit to the dipolar width in aqueous/organic systems. Here, dipolar width describes the ... -
The Role of Hydrogen Cyanide in Chemical Evolution
(1989)Two major research areas are investigated: The electrosynthesis of hydrogen cyanide; and the role of cyanocomplexes in the free - radical oligomerization of hydrogen cyanide. The electric discharge production of ... -
ROLE OF SALT BRIDGES IN GROEL ALLOSTERY
(2014)Chaperonin GroEL facilitates protein folding with two stacked back-to-back, identical rings and the "lid", co-chaperonin GroES. The mis-folded/unfolded substrate protein (SP) adjusts the chaperonin cycling from an asymmetric ... -
The role of sequence in the structure of self-assembling 3D DNA crystals
(2015)DNA is a widely used biopolymer for the construction of nanoscale objects due to its programmability and structural predictability. DNA oligonucleotides can, however, exhibit a great deal of local structural diversity. DNA ... -
The role of the F spin-orbit excited state in the F+H2 and F+HD reactions
(2004-07-22)In this dissertation we study the role of the F spin-orbit excited state (F*) in the F+H2 and F+HD reactions using quantum mechanical calculations. The calculations involve multiple potential energy surfaces (the ... -
SCAFFOLDING-MEDIATED VIRUS ASSEMBLY: VISUALIZATION AND CHARACTERIZATION OF BACTERIOPHAGE T7 SCAFFOLDING PROTEIN
(2009)In bacteriophage T7 as well as many other dsDNA phages and some animal viruses, scaffolding protein is essential for the accurate formation of the metastable precursor particle (prohead) and thus it is a vital aspect of ... -
SCANNING TUNNELING MICROSCOPY / SPECTROSCOPY STUDIES OF BINARY ORGANIC FILMS
(2009)Multi-component organic molecular films have seen increasing applications in photovoltaic technologies and other organic electronic applications. These applications have been based upon assumptions regarding film structure ... -
SCREENING FOR POTENTIAL ANTIBACTERIAL AGENTS AND THE APPLICATION OF ISOTOPIC LABELS FOR THE CHARACTERIZATION OF THEIR EFFECTS ON THE DYNAMICS OF THE BACTERIAL 16S RIBOSOMAL RNA
(2022)Antibiotic resistance is a major health challenge globally. Therefore, there is the need for new antibiotics. Here, we screen compounds with new scaffolds using nuclear magnetic resonance (NMR) spectroscopy and identified ... -
Selective [3+2] and [3+3]-Cycloaddition Reactions of Nitrones
(2012)Cationic chiral dirhodium(II,III) carboxamidates, obtained from the oxidation of the corresponding dirhodium(II,II) carboxamidates by nitrosonium salts, are efficient promoters in asymmetric Lewis acid catalyzed reactions. ... -
Selective Delivery of a Quinone Methide Precursor by Peptide Nucleic Acids
(2007-12-10)Quinone methides (QMs) are electrophilic intermediates that can be generated in vivo to alkylate DNA and function as anti-cancer drugs. Previously, DNA-QM conjugates have shown the ability to selectively deliver a QM to ... -
Selective filling of n-hexane in a tight nanopore
(Springer Nature, 2021-01-12)Molecular sieving may occur when two molecules compete for a nanopore. In nearly all known examples, the nanopore is larger than the molecule that selectively enters the pore. Here, we experimentally demonstrate the ability ... -
Self-assembly of inorganic nanoparticle amphiphiles for biomedical applications
(2015)Ensembles of interacting nanoparticles (NPs) can exhibit novel collective properties ─ arising from the coupling between NPs ─ that can be radically different from individuals. Realizing the enormous potential of NPs in ... -
Self-Assembly of Precision Polyolefin Block Copolymers and Sugar-Polyolefin Conjugates
(2018)Self-assembling materials have become ubiquitous in modern society. Thus, a great challenge exists in developing nonpolar building blocks for self-assembling materials in a simple, efficient, and scalable manner. It is ... -
SELF-ORGANIZATION IN FULLERENE THIN FILMS ON METAL SURFACES
(2014)Since the 1985 discovery of C60, fullerenes have emerged as key nanoelectronic components and promising biomedical probes. Understanding how to direct-and switch-the packing arrangements of fullerenes and their chemical ...