Browsing Chemistry & Biochemistry by Title
Now showing items 166-185 of 553
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EMPLOYING A REMOTE CONFORMATIONAL BIAS, INHIBITION OF GAMMA-BUTYROLACTONE FORMATION, AND A SODIUM TEMPLATE TO ENHANCE MACROCYCLIZATION IN CARBENE ADDITION REACTIONS
(2005-09-19)Ring closure via dirhodium(II) catalyzed diazo decomposition of diazoacetates is an efficient method of asymmetric macrocycle formation, affording up to 28-membered rings without the high dilution requirement of many other ... -
End-Group Functionalized Poly(α-olefinates) as Modular Building Blocks
(2016)The development of living coordination chain transfer polymerization (LCCTP) has provided a viable path to practical and scalable bulk quantities of structurally well-defined polyolefins that are further characterized by ... -
ENZYME-FREE UBIQUITIN LIGATION. FROM NATIVE CHEMICAL LIGATION AND SPIN LABELING TO DIMERIZATION BY INTER-UBIQUITIN MIMICKING LINKAGE AND PH-DEPENDENT CONFORMATIONAL SWITCH
(2016)The delicate balance between the production and disposal of proteins is vital for the changes required in the cell to respond to given stimulus. Ubiquitination is a protein modification with a range of signaling outcomes ... -
Epigenetics of Neurodegeneration: Quantification of Histone Deacetylase Isoforms and Post-translational Modifications of Histones in Alzheimer’s Disease
(2015)Histone post-translational modifications have been implicated in many biological functions and diseases and serve an important role in epigenetic regulation of gene expression. Aberrant modulations in histone post-translational ... -
EPIGENETICS TUNE CHROMATIN MECHANICS, A COMPUTATIONAL APPROACH
(2021)The base unit of DNA packaging in eukaryotes, the nucleosome, is adaptively modified for epigenetic control. Given the vast chemical space of chromatin and complexity of signaling and expression, much of our knowledge about ... -
Equilibrium free energies from nonequilibrium simulations: Improving convergence by reducing dissipation
(2011)The estimation of equilibrium free energy differences is an important problem in computational thermodynamics, with applications to studies of ligand binding, phase coexistence and phase equilibrium, solvation of small ... -
Ethylene Polymerization Using a Zirconium Amidinate Supported Catalyst
(2004-05-07)A series of W. R. Grace Davison IOLA(TM), methylaluminoxane-silica (MAO/Silica) and MAO/IOLA support materials were used to activate and immobilize a zirconium amidinate single site catalyst of the formula Cp*ZrMe2[tBuNC(Me)NCEt]. ... -
EVALUATING IN VITRO AND IN VIVO LOOPING EFFICIENCIES OF ARTIFICIAL DNA-BINDING PROTEINS
(2014)DNA looping plays an important role in gene regulation by increasing the local concentration of a transcriptional activator or repressor at its primary binding site. Several <italic>in vitro</italic> and <italic>in ... -
Evaluating the Stratospheric Loading of Halogens: Brominated Very Short-Lived Substances and Lower Stratospheric Inorganic Chlorine
(2018)Bromine and chlorine compounds catalyze the removal of stratospheric ozone. The Montreal Protocol and subsequent regulations have decreased the atmospheric abundance of anthropogenic, long-lived halogen sources. This ... -
Evaluation of Acetonitrile Precipitation as a Method for Separating Small from High Molecular Mass Proteins in Cytosol from MCF-7 Breast Cancer Cells.
(2004-05-18)Acetonitrile precipitation has been carried out as an investigative method for separating small from high molecular mass proteins. The separation has been visualized on a 1-D gel electrophoresis. Acetonitrile helps drive ... -
EVALUATION OF MASS FILTERED, TIME DILATED, TIME-OF-FLIGHT MASS SPECTROMETRY
(2010)The Naval Research Laboratory's Trace Element Accelerator Mass Spectrometer (NRL-TEAMS) system offers a unique opportunity to develop a new type of time-of-flight (TOF) SIMS. This opportunity derives from use of a Pretzel ... -
Examination of Dynamic Processes in Living Ziegler-Natta Polymerization and New Polypropylene Architectures through Bimolecular Control
(2006-11-24)The cationic cyclopentadienyl zirconium acetamidinate (CPZA) complex {Cp*ZrMe[N(Et)C(Me)N(tBu)]}[B(Csub6 Fsub5)sub4], (Cp* = ηsup5-Csub5Mesub5) generated through activation of Cp*ZrMesub2[N(Et)C(Me)N(tBu)] via protonolysis ... -
AN EXAMINATION OF HYDROXYL RADICAL: OUR CURRENT UNDERSTANDING OF THE OXIDATIVE CAPACITY OF THE TROPOSPHERE THROUGH EMPIRICAL, BOX, AND GLOBAL MODELING APPROACHES
(2016)Hydroxyl radical (OH) is the primary oxidant in the troposphere, initiating the removal of numerous atmospheric species including greenhouse gases, pollutants that are detrimental to human health, and ozone-depleting ... -
EXCITON ENGINEERING THROUGH TUNALBLE FLUORESCENT QUANTUM DEFECTS
(2016)This thesis demonstrates exciton engineering in semiconducting single-walled carbon nanotubes through tunable fluorescent quantum defects. By introducing different functional moieties on the sp2 lattice of carbon nanotubes, ... -
Exciton Photophysics at Fluorescent Quantum Defects
(2018)Fluorescent quantum defect is an emerging synthetic structure that can be covalently attached to a semiconducting single-walled carbon nanotube. Incorporation of fluorescent quantum defect breaks the symmetry of carbon ... -
Expanding the Range of Polyolefins through Living Coordinative Chain Transfer Polymerization
(2012)The strategy, termed living coordinative chain-transfer polymerization (LCCTP), has been explored to boost the efficiency and versatility of polyolefin synthesis by coupling a reversible chain-transfer process with living ... -
EXPANDING THE TOOLKIT: STRUCTURE, DYNAMICS, AND DRUG INTERACTIONS OF THE “PRIMING LOOP” FROM HEPATITIS B VIRUS PRE-GENOMIC RNA BY SOLUTION NMR SPECTROSCOPY
(2022)RNAs are dynamic macromolecules that function as essential components of biological pathways that result in human disease, making them attractive therapeutic targets. Yet, RNA structural biology lags significantly behind ... -
Experimental, Computational and, Theoretical Analysis of the GroEL/GroES Catalytic Cycle
(2014)The GroEL/GroES system is among the best characterized molecular chaperonins, having been the focus of numerous studies since its discovery just over 40 years ago. There are several aspects of the chaperonin's catalytic ... -
EXPLORATION OF NOVEL METHODS FOR THE FABRICATION AND CHARACTERIZATION OF ORGANIC FIELD-EFFECT TRANSISTORS AND EXAMINATION OF FACTORS INFLUENCING OFET PERFORMANCE
(2009)This thesis explores novel methods for fabricating organic field effect transistors (OFETs) and characterizing OFET devices. Transfer printing is a promising process for fabricating organic thin-film devices. In this ... -
EXPLORING ENDOGLYCOSIDASES FOR ANTIBODY GLYCOENGINEERING
(2019)Monoclonal antibodies (mAbs) comprise a rapidly growing class of therapeutics with great potential in treating infections, inflammations, cancers, and autoimmunities. The glycosylation of an antibody determines its functional ...