Browsing Chemistry & Biochemistry by Title
Now showing items 500-519 of 553
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Tailoring Guanosine Hydrogels for Various Applications
(2018)Supramolecular hydrogels are of current interest for their ease of use, potential biocompatibility, and reactivity to stimuli. These gel materials have found use in a number of fields ranging from drug delivery and tissue ... -
TAILORING PROPERTIES AND FUNCTIONALITIES OF NANOSTRUCTURES THROUGH COMPOSITIONS, COMPONENTS AND MORPHOLOGIES
(2013)The field of nanoscience and nanotechnology has made significant progresses over the last thirty years. Sophisticated nanostructures with tunable properties for novel physics and applications have been successfully fabricated, ... -
Tandem Reduction/Cyclization of o-Nitrophenyl Propargyl Alcohols--A Novel Synthesis of 2- & 2,4-Disubstituted Quinolines and Application to the Synthesis of Streptonigrin
(2008-05-23)The quinoline ring system is a common structural component of a wide variety of natural products with highly desirable biological activity, including antimalarial agents such as quinine, chloroquine and mefloquine, as well ... -
Target Alkylation of Single and Double Strand DNA by Peptide Nucleic Acids
(2011)Quinone methides (QMs) generated in vivo can alkylate DNA and function as anti-cancer drugs. Delivery of QMs to target DNA is necessary to reduce the side effects caused by indiscriminate reaction. Previous, DNA was ... -
TARGETING BIOMARKERS VIA CITP-BASED SELECTIVE PROTEOME ENRICHMENT
(2008-06-30)Besides the complexity of protein samples, probably the greatest challenge presently facing comprehensive proteome analysis is related to the large variation of protein relative abundances (>6 orders of magnitude), having ... -
A TEMPERATURE-CONTROLLED ELECTROCHEMICAL MICROSCALE PLATFORM FOR BIOMOLEMULAR BINDING STUDIES
(2014)Electrochemical detection of nucleic acids has been a very important research area in the past several decades. In this research field, the stability of the nucleic acid structure is important and crucial for many aspects ... -
TEMPLATE SYNTHESIZED NANOTUBES, NANOWIRES AND HETEROGENEOUS COAXIAL NANOWIRES FOR ELECTROCHEMICAL ENERGY STORAGE
(2009)Template synthesized nanomaterials have been successfully applied in electrochemical energy storage systems such as supercapacitors and lithium ion batteries. The first part of present study will list examples of applying ... -
Templated Synthesis of Glycoluril Oligomers and Monofunctionalized Cucurbit[6]uril Derivatives
(2011)The molecular recognition properties exhibited by molecular containers have inspired supramolecular chemists to generate diverse and specialized macrocycles. The family of hosts known as cucurbiturils (CB[n]) have become ... -
Terrace Width Distribution and First Passage Probabilities for Interacting Steps
(2005-12-05)Stochastic behavior of steps and inter-step distance is studied using Monte Carlo simulation. Terrace-step-kink model is used to represent vicinal surfaces. These vicinal surfaces consist of steps and the space between ... -
Theoretical and Experimental Investigations of High Spin Ionic Intermediates
(2007-11-20)In order to identify high-spin organic intermediates that could potentially be used as building blocks for the construction of high-spin organic ferromagnets, density functional theory (DFT) computations were performed to ... -
THEORETICAL INVESTIGATION OF COLLISIONS OF CH2 WITH He: ENERGY TRANSFER WITHIN AND BETWEEN THE a ̃ AND X ̃ ELECTRONIC STATES OF CH2
(2014)This dissertation focuses on energy transfer (rotational, vibrational, and electronic) of CH<sub>2</sub> in its ground and first excited electronic states (X<super>3</super>B<sub>1</sub> and a<super>1</super>A<sub>1</sub>), ... -
THERMAL IMAGING OF MULTIWALLED CARBON NANOTUBES
(2010)Since early days of their discovery, it has been realized that Carbon Nanotubes (CNTs) have an unusually high thermal conductivity. Unfortunately, the amount of heat they can transfer from one medium to another can be ... -
A Thermodynamic Investigation into the Allosteric Activation Mechanism of the Biotin Repressor
(2004-11-05)The biotin regulatory system of Escherichia coli serves as a model for investigating the regulatory mechanism of a non-classical allosteric transcription factor. The central protein, BirA, functions as both an essential ... -
THERMODYNAMIC PROPERTIES OF THE UNFOLDED ENSEMBLE OF PROTEINS
(2010)A random coil, whose size is determined by its excluded volume, and net energetic interactions with its environment, has served as a representation of the unfolded ensemble of proteins. The work in this thesis involves ... -
THERMODYNAMICS AND APPLICATION OF A PAIR OF SYNTHETIC NUCLEOBASES FROM ARTIFICIALLY EXPANDED GENETIC INFORMATION SYSTEM
(2016)UV-melting experiments were performed on 9-mer duplexes containing a pair of synthetic nucleobases P·Z, two members of Expanded Genetic Information System (AEGIS), or P, Z containing mismatches. Enthalpy, entropy and free ... -
Top-Down Analysis of Bacterial Proteins by High-Resolution Mass Spectrometry
(2010)In the biodefense and medical diagnostic fields, MALDI mass spectrometry-based systems are used for rapid characterization of microorganisms generally by detecting and discriminating the highly abundant protein mass-to-charge ... -
Topics in equilibrium and nonequilibrium thermodynamics: computing crystalline free energies and engineering Maxwell’s demon.
(2015)This dissertation covers two separate topics in statistical physics. The first part of the dissertation focuses on computational methods of obtaining the free energies (or partition functions) of crystalline solids. We ... -
Total Synthesis of (3R,3'R,6'R)-Lutein, (3R,3'R)-Zeaxanthin and Their Stereoisomers
(2008)(3R,3'R,6'R)-Lutein (1) and (3R,3'R)-zeaxanthin (5) are dietary carotenoids that are found in most fruits and vegetables. Numerous studies have shown that 1 and 5 play an important role in the prevention of age-related ... -
Total Synthesis of an Oxidation Product of gamma-Carotene - a ProVitamin A Food Carotenoid
(2011)Human serum carotenoids and their metabolites are known to function as antioxidants and inflammation mediators. In 1992, two oxidative metabolites of lycopene were isolated from human serum and tomato-based food products. ... -
TOWARD IN SITU MEASUREMENT OF LIQUID DENSITY USING OPTICAL KERR EFFECT SPECTROSCOPY
(2016)Optical Kerr effect (OKE) spectroscopy is a widely used technique for probing the low-frequency, Raman-active dynamics of liquids. Although molecular simulations are an attractive tool for assigning liquid degrees of freedom ...