Browsing Chemistry & Biochemistry by Title
Now showing items 423-442 of 553
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SCAFFOLDING-MEDIATED VIRUS ASSEMBLY: VISUALIZATION AND CHARACTERIZATION OF BACTERIOPHAGE T7 SCAFFOLDING PROTEIN
(2009)In bacteriophage T7 as well as many other dsDNA phages and some animal viruses, scaffolding protein is essential for the accurate formation of the metastable precursor particle (prohead) and thus it is a vital aspect of ... -
SCANNING TUNNELING MICROSCOPY / SPECTROSCOPY STUDIES OF BINARY ORGANIC FILMS
(2009)Multi-component organic molecular films have seen increasing applications in photovoltaic technologies and other organic electronic applications. These applications have been based upon assumptions regarding film structure ... -
SCREENING FOR POTENTIAL ANTIBACTERIAL AGENTS AND THE APPLICATION OF ISOTOPIC LABELS FOR THE CHARACTERIZATION OF THEIR EFFECTS ON THE DYNAMICS OF THE BACTERIAL 16S RIBOSOMAL RNA
(2022)Antibiotic resistance is a major health challenge globally. Therefore, there is the need for new antibiotics. Here, we screen compounds with new scaffolds using nuclear magnetic resonance (NMR) spectroscopy and identified ... -
Selective [3+2] and [3+3]-Cycloaddition Reactions of Nitrones
(2012)Cationic chiral dirhodium(II,III) carboxamidates, obtained from the oxidation of the corresponding dirhodium(II,II) carboxamidates by nitrosonium salts, are efficient promoters in asymmetric Lewis acid catalyzed reactions. ... -
Selective Delivery of a Quinone Methide Precursor by Peptide Nucleic Acids
(2007-12-10)Quinone methides (QMs) are electrophilic intermediates that can be generated in vivo to alkylate DNA and function as anti-cancer drugs. Previously, DNA-QM conjugates have shown the ability to selectively deliver a QM to ... -
Selective filling of n-hexane in a tight nanopore
(Springer Nature, 2021-01-12)Molecular sieving may occur when two molecules compete for a nanopore. In nearly all known examples, the nanopore is larger than the molecule that selectively enters the pore. Here, we experimentally demonstrate the ability ... -
Self-assembly of inorganic nanoparticle amphiphiles for biomedical applications
(2015)Ensembles of interacting nanoparticles (NPs) can exhibit novel collective properties ─ arising from the coupling between NPs ─ that can be radically different from individuals. Realizing the enormous potential of NPs in ... -
Self-Assembly of Precision Polyolefin Block Copolymers and Sugar-Polyolefin Conjugates
(2018)Self-assembling materials have become ubiquitous in modern society. Thus, a great challenge exists in developing nonpolar building blocks for self-assembling materials in a simple, efficient, and scalable manner. It is ... -
SELF-ORGANIZATION IN FULLERENE THIN FILMS ON METAL SURFACES
(2014)Since the 1985 discovery of C60, fullerenes have emerged as key nanoelectronic components and promising biomedical probes. Understanding how to direct-and switch-the packing arrangements of fullerenes and their chemical ... -
Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability
(Springer Nature, 2012-12-12)The genera Aspergillus and Penicillium include some of the most beneficial as well as the most harmful fungal species such as the penicillin-producer Penicillium chrysogenum and the human pathogen Aspergillus fumigatus, ... -
Silencing bacteria with small molecules
(2014)Quorum sensing (QS) is a phenomenon in bacteria where the accumulation of extracellular signaling molecules (autoinducers, AIs), which enable bacterial cells to sense neighboring cells (population density), reaches certain ... -
Simulation and Projection of Global Temperature Change and Recovery of Extra-polar Ozone using Multiple Linear Regression Models
(2022)Climate change and the depletion of the ozone layer are two important global environmental problems caused by the release of gases into the atmosphere. This dissertation uses multiple linear regression to quantify the ... -
Simulations of nonuniform fluids with long-ranged and short-ranged interactions
(2012)The study of nonuniform fluids is of great importance in many areas of chemistry, biophysics,and materials science. Computer simulations of model systems have provided great insight into fundamental physical issues. We ... -
Single and Multi-dimensional AAO Template Synthesized Heterogeneous Nanostructures for Electrochemical Energy Storage
(2012)Anodic aluminum oxide (AAO) has been successfully used to fabricate a variety of well-ordered, regular nanostructured systems for a range of applications including electrochemical energy storage technologies. Template ... -
SINGLE MOLECULE FLUORESCENCE INVESTIGATION OF PROTEIN FOLDING
(2008-09-30)In addition to the well known two-state folding scenario, the energy landscape theory of protein folding predicts the possibility of downhill folding under native conditions. This intriguing prediction was extended by ... -
SINGLE MOLECULE FRET OF LACI-DNA-IPTG LOOP CONFORMATIONS
(2012)This work focuses on the <italic>Escherichia coli</italic> lactose repressor protein (LacI) which represses expression of the lac operon. In order to repress transcription, the tetrameric LacI protein binds a primary ... -
SITE-DIRECTED MUTAGENESIS OF GROEL:DEVELOPING A SYSTEM FOR MONITORING ALLOSTERIC MOVEMENTS BY FLUORESCENCE RESONANCE ENERGY TRANSFER
(2007-01-02)The Escherichia coli chaperonin protein GroEL can assist protein folding to its native state through the consumption of ATP. Accompanying this process, GroEL undergoes structural change, resulting in an expansion of the ... -
SITE-SPECIFIC INTERACTION OF DOXORUBICIN IN THE IRON RESPONSIVE ELEMENT RNA: IMPLICATIONS IN CELLULAR IRON HOMEOSTASIS AND NON-IRON DEFICIENCY ANEMIA
(2014)A widely utilized chemotherapy drug, doxorubicin, has recently been shown to bind to a mammalian 5′ untranslated region Iron Responsive Element (IRE) RNA. In conjunction with the Iron Regulatory Protein (IRP), IRE ... -
The small mechanosensitive channel: Adaptive gating and timing during hypoosmotic shock.
(2011)Mechanosensation is the ability to respond to mechanical stimuli. It is present in many organisms. In Escherichia coli (E. coli), mechanosensation manifests in two membrane channels, the large mechanosensitive channel ... -
Small Molecule Activation and Atom and Group Transfer Reactions Mediated by Mid Valent Group 6 'CPAM' Complexes
(2015)The use of organometallic compounds to activate small molecules (e.g. CO2, N2, N2O, O2, etc.) has long been of significant scientific interest. Described here is the synthesis and characterization of mid valent group 6 ...