Browsing Chemistry & Biochemistry by Title
Now showing items 102-121 of 553
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DEGENERATIVE TRANSFER LIVING ZIEGLER-NATTA POLYMERIZATION OF α-OLEFINS
(2005-12-04)A degenerative transfer (DT) living Ziegler-Natta polymerization system based on the cyclopentadienyl amidinate zirconium complex, (h5-C5Me5)ZrMe2[N(t-Bu)C(Me)N(Et)] (19), has been studied in detail. Compound 19 is an ... -
Dendritic Integration and Reciprocal Inhibition in the Retina
(2008-11-17)The mammalian retina is capable of signaling over a vast range of mean light levels (~10^10). Such a large dynamic range is achieved by segregating signals into contrasting pathways and utilizing excitatory and inhibitory ... -
DENSITY FUNCTIONAL CALCULATIONS OF BACKBONE 15N CHEMICAL SHIELDINGS IN PEPTIDES AND PROTEINS
(2009)In this dissertation, we describe computational and theoretical study of backbone 15N chemical shieldings in peptides and proteins. Comprehensive density functional calculations have been performed on systems of different ... -
DESIGN AND DEVELOPMENT OF THREE-DIMENSIONAL DNA CRYSTALS UTILIZING CGAA PARALLEL BASE PAIRED MOTIFS
(2013)Three-dimensional (3D) DNA crystals hold great potential for various applications such as the development of molecular scaffolds for use in protein structure determination by x-ray crystallography. The programmability and ... -
DESIGN AND HIERARCHICAL ASSEMBLY OF AMPHIPHILIC SUPRACOLLOIDS THAT MIMIC BIMOLECULAR COMPOUNDS
(2018)Self-assembly of nanoparticles (NPs) into desired structures with precisely controlled NP organization is crucial to the property discovery and application of inorganic NPs. Despite tremendous efforts made in the past ... -
DESIGN AND SYNTHESIS OF AN ELECTRON RICH QUINONE METHIDE PRECURSOR FOR SEQUENCE -DIRECTED ALKYLATION OF DNA
(2012)Quinone methides (QM) can be delivered to alklyate specific sites with a single strand DNA through target promoted alkylation. Previous experimental results indicated that alkylation by DNA-QM self-adduct was too slow for ... -
Design and Synthesis of New Group (IV) Cyclopentadienyl Amidinate and Guanidinate Initiators for Controlling the Microstructure of Poly(α-olefins) During Living Coordinative Chain Transfer Polymerizations
(2014)C1-symmetric, cationic group 4 metal (Zr and Hf) mono-methyl complexes, {(η5-C5Me5)M[N(tBu)C(Me)N(Et)](Me)}[B(C6F5)4], are highly active initiators for the living and stereo-selective (isotactic) coordinative ... -
DESIGN OF HYBRID POLYMER- INORGANIC NANOASSEMBLIES FOR BIOMEDICAL APPLICATIONS
(2018)Assembly of inorganic nanoparticles (NPs) can give rise to novel collective properties due to the coupling between adjacent subunits, which are not accessible from individual nanoparticles. Among them, hybrid polymer-inorganic ... -
DESIGN, SYNTHESIS, AND ANTIBODY BINDING STUDIES OF HIV-ASSOCIATED CARBOHYDRATE ANTIGENS
(2016)The development of an effective prophylactic human immunodeficiency virus (HIV) vaccine is a critical global health priority. However, to-date, all efforts to design an HIV vaccine have been met with a paucity of success. ... -
Designing Hydrogels that Transform their Shape in Response to Molecular Cues
(2016)There has been considerable interest in developing shape-changing soft materials for potential applications in drug delivery, microfluidics and biosensing. These shape- changing materials are inspired by the morphological ... -
A Deuterium Labeling Method for the Characterization of (Chromophoric) Dissolved Organic Matter Using Ultrahigh Resolution Electrospray Ionization Mass Spectrometry
(2015)Dissolved organic matter (DOM) is a complex ensemble of naturally occurring organic compounds found in virtually all aquatic environments. The overwhelming diversity of DOM makes it extremely difficult to understand the ... -
DEVELOPING A NEW MODEL OF THE GROEL FUNCTIONAL CYCLE AND ITS IMPLICATIONS FOR THE GROEL-OPTIMIZED SUBSTRATE PROTEIN REFOLDING
(2014)Despite years of research work, many aspects of the fundamentally important GroEL functional cycle are still in dispute. The work of this dissertation mainly focuses on three major disputes in the field: the identity of ... -
THE DEVELOPMENT AND APPLICATION OF SITE-SELECTIVELY ISOTOPICALLY LABELED NUCLEOTIDES TO PROBLEMS IN NMR SPECTROSCOPY:STRUCTURAL INSIGHTS INTO THE EPSILON RNA AND TARGET COMPOUND INTERACTIONS
(2017)RNA plays a central role in a multitude of cellular processes. Understanding the complex interplay between its structure and function is a requisite for understanding these cellular roles mechanisms of action. Herein we ... -
THE DEVELOPMENT AND APPLICATION OF TRANSPOSON MUTAGENESIS AND UNNATURAL AMINO ACID MUTAGENESIS TECHNOLOGIES
(2012)Recent three decades have seen a significant progress in the protein engineering field. Protein engineering has not only facilitated our understanding of the sequence-structure-function relationship of proteins, but also ... -
Development and applications of codon scanning mutagenesis: A novel mutagenesis method that facilitates in-frame codon mutations
(2009)The ability to create protein variants is a very valuable tool in biochemistry. Information about mechanistic roles of amino acid side chains, protein topology and binding can all be obtained. Methodologies to mutate ... -
DEVELOPMENT OF A MICROSCALE ELECTROCHEMICAL PLATFORM FOR THE ANALYSIS OF THERMAL PROFILES OF IMMOBILIZED DNA SECONDARY STRUCTURES
(2019)Understanding the thermal stability of DNA secondary structures is important to the pharmaceutical industry, as drug molecules that strongly bind will increase the stability of the structure, leading to higher measured ... -
DEVELOPMENT OF A PROTEOMIC STRATEGY FOR ANALYSIS OF PLASMA MEMBRANE PROTEINS
(2013)Plasma membrane (PM) proteins play crucial roles in cell signaling and communications, and they are the targets of more than two thirds of drugs currently under development. Studies on changes in protein content, quantity ... -
DEVELOPMENT OF ARYL SILOXANE CROSS-COUPLING TECHNOLOGY AND ITS APPLICATION TO THE SYNTHESIS OF COLCHICINE AND ALLOCOLCHICINE DERIVATIVES
(2005-09-27)One of the most versatile methods for the formation of aryl-aryl bonds is the palladium-catalyzed cross-coupling reaction. Previous work in the DeShong laboratory has demonstrated the utility of aryl siloxanes for the ... -
DEVELOPMENT OF ION-MOBILITY AND MASS SPECTROMETRY FOR PROBING THE REACTIVITY OF NANOPARTICLES AND NANOCOMPOSITES
(2009)Aerosols of diameter smaller than 100 nm, usually are referred as nanoparticles or ultrafines, have received considerable interests lately as a source of building blocks to novel materials. However, our capabilities for ... -
Development of Magnetic Nanoparticle-based Enrichment Techniques and Mass Spectrometry Methods for Quantification of the Clinical Biomarker Cardiac Troponin I
(2016)Human cardiac troponin I (cTnI) in serum is a well-known clinical biomarker for cardiac tissue damage and is used for diagnosing myocardial infarction. Unfortunately, commercial cTnI immunoassays from different manufacturers ...