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    Association between Allostatic Load and Arthritis in NHANES Adults

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    No. of downloads: 995

    Date
    2010
    Author
    Scully, Lynn
    Advisor
    Lee, Sunmin
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    Abstract
    Objective: To examine the cross-sectional association between allostatic load and arthritis using data from the National Health and Nutrition Examination Survey (NHANES). Methods: Complete data on 7,714 adults were included in the analysis. An allostatic load (AL) index, comprising of multiple regulatory systems, was calculated from 11 biomarkers. Multivariate logistic regression was used to estimate the odds ratio (OR) for the association between allostatic load and arthritis, while accounting for confounders. Results: Significant positive associations were found between both continuous allostatic load (OR=1.12, 95% CI= 1.08-1.17) and the two highest quartile categories of AL and arthritis compared to the lowest quartile (quartile 3: OR=1.73, 95% CI=1.38-2.17, quartile 4: OR=1.79, 95% CI=1.41-2.26), after adjusting for confounders. The subscales of the inflammatory (OR=1.27, 95% CI=1.15-1.40) and metabolic system (OR=1.20, 95% CI=1.13-1.28) were also significant predictors. Conclusions: Cumulative biological risk is a plausible mechanism that is associated with arthritis.
    URI
    http://hdl.handle.net/1903/10451
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    • Epidemiology & Biostatistics Theses and Dissertations
    • UMD Theses and Dissertations

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    DRUM is brought to you by the University of Maryland Libraries
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