A. James Clark School of Engineering

Permanent URI for this communityhttp://hdl.handle.net/1903/1654

The collections in this community comprise faculty research works, as well as graduate theses and dissertations.

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Subject: search.filters.subject.multilayer

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    Engineering Cell Surfaces with Polyelectrolyte Materials for Translational Applications
    (MDPI, 2017-01-28) Zhang, Peipei; Bookstaver, Michelle L.; Jewell, Christopher M.
    Engineering cell surfaces with natural or synthetic materials is a unique and powerful strategy for biomedical applications. Cells exhibit more sophisticated migration, control, and functional capabilities compared to nanoparticles, scaffolds, viruses, and other engineered materials or agents commonly used in the biomedical field. Over the past decade, modification of cell surfaces with natural or synthetic materials has been studied to exploit this complexity for both fundamental and translational goals. In this review we present the existing biomedical technologies for engineering cell surfaces with one important class of materials, polyelectrolytes. We begin by introducing the challenges facing the cell surface engineering field. We then discuss the features of polyelectrolytes and how these properties can be harnessed to solve challenges in cell therapy, tissue engineering, cell-based drug delivery, sensing and tracking, and immune modulation. Throughout the review, we highlight opportunities to drive the field forward by bridging new knowledge of polyelectrolytes with existing translational challenges.
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    Investigation of Reactively Structured Al/Ni Multilayer Foils and their Applications in High Temperature Die Attach
    (2008-11-25) McClure, Adam; McCluskey, Patrick; Material Science and Engineering; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    This work focuses on using a reactive layered Al/Ni foil as a localized heat source for electronic die attachment purposes. A two pronged approach was used to demonstrate the viability of this material for attaching die to substrates using AuSn braze. Both experimental sample creation and transient thermal modeling were conducted. This thesis will report thermal simulation and experimental results as well as discussing the joining process and the results of shear strength and thermal cycling reliability testing. A new pre-heating method was developed after results revealed that the initial temperature of the system is vital in predicting how successful a joint will be. Thermal cycling results have shown that die cracking is a significant reliability issue but with further study this reactive joining process shows promise.