Theses and Dissertations from UMD

Permanent URI for this communityhttp://hdl.handle.net/1903/2

New submissions to the thesis/dissertation collections are added automatically as they are received from the Graduate School. Currently, the Graduate School deposits all theses and dissertations from a given semester after the official graduation date. This means that there may be up to a 4 month delay in the appearance of a give thesis/dissertation in DRUM

More information is available at Theses and Dissertations at University of Maryland Libraries.

Browse

Filters

2010 - 20152

Settings

Subject: search.filters.subject.C-reactive protein

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Association Between C-Reactive Protein and Serum 25-Hydroxyvitamin D: A Negative Acute Phase Reactant
    (2015) Verdin, Kelly; Lee, Sunmin; Epidemiology and Biostatistics; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Objective: The aims of this study were to determine whether serum 25-hydroxyvitamin-D (25-OH-vitamin D) is a negative acute phase reactant and whether class of diagnosis modifies the association between C-Reactive Protein (CRP) and 25-OH-vitamin D. Methods: Multiple linear regression analysis was utilized to assess the association between CRP and 25-OH-vitamin D in 1,043 patients with acute and chronic diseases and normal volunteers. Results: After adjusting for confounding factors, the association between CRP and 25-OH-vitamin D was statistically significant. Class of diagnosis did not modify this association. Conclusions: 25-OH-vitamin D is demonstrated to be a negative acute phase reactant in this group of patients; Therefore, it is not an accurate marker of vitamin D status in the setting of inflammation. These findings support that 25-OH-vitamin D should be interpreted cautiously when CRP is elevated and that evaluating 25-OH-vitamin D in the context of CRP will improve accuracy of 25-OH-vitamin D interpretation.
  • Thumbnail Image
    Item
    HYPERLEPTINEMIA, METABOLIC SYNDROME, AND MORTALITY IN OLDER ADULTS
    (2010) Mishra, Suruchi; Sahyoun, Nadine R; Mehta, Mira; Nutrition; Digital Repository at the University of Maryland; University of Maryland (College Park, Md.)
    Background: Abdominal adiposity and fat mass increase with aging, and as does insulin resistance which is frequently associated with hyperleptinemia and leptin resistance. Serum leptin may predict risk of metabolic syndrome and mortality among older adults. Objectives: The objectives of the present study were to evaluate the relationship of serum leptin with risk of metabolic syndrome and mortality and to examine these associations in relation to the measures of body adiposity and proinflammatory cytokines. The influence of leptin receptor (I/D) gene polymorphism on diabetes as a contributing cause of mortality was also examined. Gender specific serum leptin cut off values as a biomarker for the risk of metabolic syndrome were determined. Design: The Health, Aging and Body Composition (HABC) study is a prospective cohort of 3,075 older adults aged 70 to 79 years. Body composition, demographic information, biochemical variables including, markers of systemic inflammation, and genetic variation were assessed in detail. Results: Women in quintile 2, 3, 4 and 5 of serum leptin were at significantly lower risk for metabolic syndrome as compared to those in quintile 1 after controlling for confounders. Serum leptin was independently associated with risk of metabolic syndrome after sequentially adjusting for demographic variables (p<0.0001), fat depots (p=.0024), and proinflammatory cytokines (p=.0098) in women. Among men, the association between serum leptin and risk of metabolic syndrome was explained by body adiposity. Women in quartile 2 and 3 of serum leptin were at lower risk than women in quintile 1 for all-cause mortality and mortality from cardiovascular disease independent of body fat and proinflammatory cytokines. Additionally, elevated level of serum leptin was associated with increased risk for diabetes as a contributing cause of mortality for both genders after sequentially adjusting for potential confounders, body fat and proinflammatory cytokines. Significant interaction was found between leptin receptor genotype and total percent fat (p=0.008) in association with diabetes as a contributing cause of mortality among women. The cut off serum leptin level that suggests the possible risk of metabolic syndrome was determined to be 6.45 ng/ml with 60% sensitivity and 63% specificity among men and 18.25 ng/ml with 55% sensitivity and 62% specificity among women. Conclusion: Elevated levels of serum leptin may be associated with increased risk of metabolic syndrome and risk of diabetes as a contributing cause of mortality among older women. However, intermediary levels of serum leptin may lower the risk of all-cause mortality and mortality from CVD, suggesting a paradoxical association of serum leptin with cardiovascular risk factors and mortality from CVD among older women